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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F12%3A00377359%21RIV13-AV0-67985823
rdf:type
skos:Concept n3:Vysledek
dcterms:description
Disruption of BMH1 in S. cerevisiae, encoding the major 14-3-3 isoform, resulted in an increased sensitivity to Na+, Li+ and K+ and to cationic drugs. BMH1 deletion did not affect plasma membrane potential. Testing the genetic interaction between BMH genes and genes encoding five plasma-membrane potassium and sodium transporters revealed, that 14-3-3 proteins neither interact with the potassium uptake systems, nor with the potassium-specific channel nor with the Na+(K+)-ATPases. Instead, a genetic interaction was identified between BMH1 and NHA1 which encodes an Na+(K+)/H+ antiporter Disruption of BMH1 in S. cerevisiae, encoding the major 14-3-3 isoform, resulted in an increased sensitivity to Na+, Li+ and K+ and to cationic drugs. BMH1 deletion did not affect plasma membrane potential. Testing the genetic interaction between BMH genes and genes encoding five plasma-membrane potassium and sodium transporters revealed, that 14-3-3 proteins neither interact with the potassium uptake systems, nor with the potassium-specific channel nor with the Na+(K+)-ATPases. Instead, a genetic interaction was identified between BMH1 and NHA1 which encodes an Na+(K+)/H+ antiporter
dcterms:title
Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter
skos:prefLabel
Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter
skos:notation
RIV/67985823:_____/12:00377359!RIV13-AV0-67985823
n3:predkladatel
n4:ico%3A67985823
n5:aktivita
n17:Z n17:P n17:I
n5:aktivity
I, P(IAA500110801), P(LC531), P(OC10012), Z(AV0Z50110509)
n5:cisloPeriodika
7
n5:dodaniDat
n12:2013
n5:domaciTvurceVysledku
n9:4235401 n9:9978194
n5:druhVysledku
n18:J
n5:duvernostUdaju
n16:S
n5:entitaPredkladatele
n20:predkladatel
n5:idSjednocenehoVysledku
181235
n5:idVysledku
RIV/67985823:_____/12:00377359
n5:jazykVysledku
n10:eng
n5:klicovaSlova
yeast; 14-3-3 proteins; ion homeostasis; Nha1 antiporter
n5:klicoveSlovo
n6:ion%20homeostasis n6:Nha1%20antiporter n6:yeast n6:14-3-3%20proteins
n5:kodStatuVydavatele
NL - Nizozemsko
n5:kontrolniKodProRIV
[6B98DB9795DB]
n5:nazevZdroje
Biochimica et Biophysica Acta. General Subjects
n5:obor
n15:CE
n5:pocetDomacichTvurcuVysledku
2
n5:pocetTvurcuVysledku
3
n5:projekt
n19:LC531 n19:IAA500110801 n19:OC10012
n5:rokUplatneniVysledku
n12:2012
n5:svazekPeriodika
1820
n5:tvurceVysledku
Zahrádka, Jaromír Sychrová, Hana Van Heusden, G.P.H.
n5:wos
000305366100007
n5:zamer
n13:AV0Z50110509
s:issn
0304-4165
s:numberOfPages
10
n14:doi
10.1016/j.bbagen.2012.03.013