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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F11%3A00369728%21RIV12-AV0-67985823
rdf:type
skos:Concept n10:Vysledek
dcterms:description
The molecular mechanisms underlying the spatiotemporal development and environmental resistance of biofilms and colonies remain largely unknown. We show that a biofilm yeast colony is a finely tuned, complex ’multicellular organism, in which specialized cells jointly execute multiple protection strategies. These include a Pdr1p-regulated mechanism whereby multidrug-resistance transporters Pdr5p and Snq2p expel external compounds solely within the surface cell layers, as well as developmentally regulated production by internal cells of a selectively permeable extracellular matrix. The two mechanisms act in concert during colony development, allowing growth of new cell generations in a well protected, internal cavity of the colony. Colony architecture is strengthened by intercellular fiber connections The molecular mechanisms underlying the spatiotemporal development and environmental resistance of biofilms and colonies remain largely unknown. We show that a biofilm yeast colony is a finely tuned, complex ’multicellular organism, in which specialized cells jointly execute multiple protection strategies. These include a Pdr1p-regulated mechanism whereby multidrug-resistance transporters Pdr5p and Snq2p expel external compounds solely within the surface cell layers, as well as developmentally regulated production by internal cells of a selectively permeable extracellular matrix. The two mechanisms act in concert during colony development, allowing growth of new cell generations in a well protected, internal cavity of the colony. Colony architecture is strengthened by intercellular fiber connections
dcterms:title
Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies
skos:prefLabel
Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies Flo11p, drug efflux pumps, and the extracellular matrix cooperate to form biofilm yeast colonies
skos:notation
RIV/67985823:_____/11:00369728!RIV12-AV0-67985823
n10:predkladatel
n11:ico%3A67985823
n3:aktivita
n13:P n13:Z
n3:aktivity
P(GA204/08/0718), P(LC06063), P(LC531), Z(AV0Z50110509), Z(AV0Z50200510), Z(MSM0021620858)
n3:cisloPeriodika
5
n3:dodaniDat
n20:2012
n3:domaciTvurceVysledku
n14:6691587 n14:7488459
n3:druhVysledku
n8:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
199997
n3:idVysledku
RIV/67985823:_____/11:00369728
n3:jazykVysledku
n4:eng
n3:klicovaSlova
CANDIDA-ALBICANS BIOFILMS; SACCHAROMYCES-CEREVISIAE; ABC TRANSPORTERS
n3:klicoveSlovo
n7:CANDIDA-ALBICANS%20BIOFILMS n7:SACCHAROMYCES-CEREVISIAE n7:ABC%20TRANSPORTERS
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[A0EFE1BBAC22]
n3:nazevZdroje
Journal of Cell Biology
n3:obor
n9:EE
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
7
n3:projekt
n19:LC06063 n19:GA204%2F08%2F0718 n19:LC531
n3:rokUplatneniVysledku
n20:2011
n3:svazekPeriodika
194
n3:tvurceVysledku
Hlaváček, Otakar Kubínová, Lucie Palková, Z. Chernyavskiy, Oleksandr Štěpánek, L. Váchová, Libuše Šťovíček, V.
n3:wos
000294602500006
n3:zamer
n16:AV0Z50110509 n16:AV0Z50200510 n16:MSM0021620858
s:issn
0021-9525
s:numberOfPages
9
n15:doi
10.1083/jcb.201103129