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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F11%3A00364285%21RIV12-AV0-67985823
rdf:type
skos:Concept n10:Vysledek
dcterms:description
Here, we describe a genome-wide screen for mutants that present altered tolerance to hygromycin B, spermine and tetramethylammonium. Two hundred twenty six mutant strains displayed altered tolerance to all three drugs (202 hypersensitive and 24 hypertolerant) and more than 50% presented a strong or moderate growth defect at limiting potassium (1 mM). Functional groups such as protein kinases and phosphatases, intracellular trafficking, transcription or cell cycle and DNA processing were enriched. Essentially, our screen has identified a substantial number of genes which were not previously described to play a direct or indirect role in potassium homeostasis. A subset of 27 representative mutants were selected and subjected to diverse biochemical tests that, in some cases, allow us to postulate the basis for the observed phenotypes Here, we describe a genome-wide screen for mutants that present altered tolerance to hygromycin B, spermine and tetramethylammonium. Two hundred twenty six mutant strains displayed altered tolerance to all three drugs (202 hypersensitive and 24 hypertolerant) and more than 50% presented a strong or moderate growth defect at limiting potassium (1 mM). Functional groups such as protein kinases and phosphatases, intracellular trafficking, transcription or cell cycle and DNA processing were enriched. Essentially, our screen has identified a substantial number of genes which were not previously described to play a direct or indirect role in potassium homeostasis. A subset of 27 representative mutants were selected and subjected to diverse biochemical tests that, in some cases, allow us to postulate the basis for the observed phenotypes
dcterms:title
A Genomewide Screen for Tolerance to Cationic Drugs Reveals Genes Important for Potassium Homeostasis in Saccharomyces cerevisiae A Genomewide Screen for Tolerance to Cationic Drugs Reveals Genes Important for Potassium Homeostasis in Saccharomyces cerevisiae
skos:prefLabel
A Genomewide Screen for Tolerance to Cationic Drugs Reveals Genes Important for Potassium Homeostasis in Saccharomyces cerevisiae A Genomewide Screen for Tolerance to Cationic Drugs Reveals Genes Important for Potassium Homeostasis in Saccharomyces cerevisiae
skos:notation
RIV/67985823:_____/11:00364285!RIV12-AV0-67985823
n10:predkladatel
n11:ico%3A67985823
n4:aktivita
n18:P n18:Z
n4:aktivity
P(IAA500110801), P(LC531), Z(AV0Z50110509)
n4:cisloPeriodika
9
n4:dodaniDat
n6:2012
n4:domaciTvurceVysledku
n15:4649788 n15:9978194 n15:1112368
n4:druhVysledku
n16:J
n4:duvernostUdaju
n20:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
183822
n4:idVysledku
RIV/67985823:_____/11:00364285
n4:jazykVysledku
n13:eng
n4:klicovaSlova
Potassium homeostasis; Saccharomyces cerevisiae; genomewide screen
n4:klicoveSlovo
n7:genomewide%20screen n7:Potassium%20homeostasis n7:Saccharomyces%20cerevisiae
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[DD765F02B214]
n4:nazevZdroje
Eukaryotic Cell
n4:obor
n14:EB
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
13
n4:projekt
n9:LC531 n9:IAA500110801
n4:rokUplatneniVysledku
n6:2011
n4:svazekPeriodika
10
n4:tvurceVysledku
Yenush, L. Sychrová, Hana Herrera, R. Giraldo, J. Navarrete, C. Olier, I. Petrezsélyová, Silvia Marešová, Lydie Ramos, J. Barreto, L. Ariňo, J. Canadell, D. Peréz-Valle, J.
n4:wos
000294453000010
n4:zamer
n19:AV0Z50110509
s:issn
1535-9778
s:numberOfPages
10
n17:doi
10.1128/EC.05029-11