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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F10%3A00349619%21RIV11-GA0-67985823
rdf:type
skos:Concept n13:Vysledek
dcterms:description
Mice with a whole-body deletion of the alfa2 catalytic subunit of AMPK and their wild-type littermates were used for testing a hypothesis whether AMP-activated protein kinase (AMPK) has a role in the beneficial effects of n-3 LC-PUFAs. Our results show that n-3 LC-PUFA prevent hepatic insulin resistance in an AMPKalfa2-dependent manner and support the role of adiponectin and hepatic diacylglycerols in the regulation of insulin sensitivity. AMPKα2 is also essential for hypolipidemic and antisteatotic effects of n-3 LC-PUFA under insulin-stimulated conditions Mice with a whole-body deletion of the alfa2 catalytic subunit of AMPK and their wild-type littermates were used for testing a hypothesis whether AMP-activated protein kinase (AMPK) has a role in the beneficial effects of n-3 LC-PUFAs. Our results show that n-3 LC-PUFA prevent hepatic insulin resistance in an AMPKalfa2-dependent manner and support the role of adiponectin and hepatic diacylglycerols in the regulation of insulin sensitivity. AMPKα2 is also essential for hypolipidemic and antisteatotic effects of n-3 LC-PUFA under insulin-stimulated conditions
dcterms:title
AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids
skos:prefLabel
AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids AMP-activated Protein Kinase alfa2 Subunit Is Required for the Preservation of Hepatic Insulin Sensitivity by n-3 Polyunsaturated Fatty Acids
skos:notation
RIV/67985823:_____/10:00349619!RIV11-GA0-67985823
n4:aktivita
n12:P n12:Z
n4:aktivity
P(1M0520), P(GAP301/10/1420), P(OC08007), Z(AV0Z50110509)
n4:cisloPeriodika
11
n4:dodaniDat
n8:2011
n4:domaciTvurceVysledku
n5:4332709 n5:6758932 n5:8278830 n5:6279163 n5:4429230 n5:2846535 n5:5972450 n5:6642942 n5:4671724 n5:3220184 n5:4259068
n4:druhVysledku
n6:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n11:predkladatel
n4:idSjednocenehoVysledku
246119
n4:idVysledku
RIV/67985823:_____/10:00349619
n4:jazykVysledku
n18:eng
n4:klicovaSlova
AMPK; n-3 LC-PUFA; insulin resistance
n4:klicoveSlovo
n7:AMPK n7:insulin%20resistance n7:n-3%20LC-PUFA
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[6864E4D32B3F]
n4:nazevZdroje
Diabetes
n4:obor
n16:FB
n4:pocetDomacichTvurcuVysledku
11
n4:pocetTvurcuVysledku
17
n4:projekt
n14:1M0520 n14:GAP301%2F10%2F1420 n14:OC08007
n4:rokUplatneniVysledku
n8:2010
n4:svazekPeriodika
59
n4:tvurceVysledku
Hensler, Michal Jeleník, Tomáš Medříková, Daša Mikšík, Ivan Viollet, B. Flachs, Pavel Hawley, S. Kuda, Ondřej Rossmeisl, Martin Macek Jílková, Zuzana Kůs, Vladimír Jensen, T. E. Kopecký, Jan Gorski, J. Hébrard, S. Baranowski, M. Janovská, Petra
n4:wos
284133400009
n4:zamer
n17:AV0Z50110509
s:issn
0012-1797
s:numberOfPages
10