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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F10%3A00345059%21RIV11-MSM-67985823
rdf:type
n4:Vysledek skos:Concept
dcterms:description
We investigated the functional characteristics of pre- and postsynaptic cholinergic transmission in APPswe/PS1dE9 double transgenic mice at a young age (7-10 weeks) before the onset of amyloid plaque formation and at adult age (5-6 months) at its onset. Our results indicate that functional pre- and postsynaptic cholinergic deficits are nor present in APPswe/PS1dE9 transgenic mice before 10 weeks of age, but develop along with beta-amyloid accumulation in the brain We investigated the functional characteristics of pre- and postsynaptic cholinergic transmission in APPswe/PS1dE9 double transgenic mice at a young age (7-10 weeks) before the onset of amyloid plaque formation and at adult age (5-6 months) at its onset. Our results indicate that functional pre- and postsynaptic cholinergic deficits are nor present in APPswe/PS1dE9 transgenic mice before 10 weeks of age, but develop along with beta-amyloid accumulation in the brain
dcterms:title
Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice
skos:prefLabel
Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice
skos:notation
RIV/67985823:_____/10:00345059!RIV11-MSM-67985823
n5:aktivita
n10:Z n10:P
n5:aktivity
P(IAA500110703), P(LC554), Z(AV0Z50110509)
n5:cisloPeriodika
1
n5:dodaniDat
n8:2011
n5:domaciTvurceVysledku
n12:8776911 n12:7698291 n12:9133933 n12:6487890
n5:druhVysledku
n11:J
n5:duvernostUdaju
n9:S
n5:entitaPredkladatele
n17:predkladatel
n5:idSjednocenehoVysledku
259933
n5:idVysledku
RIV/67985823:_____/10:00345059
n5:jazykVysledku
n15:eng
n5:klicovaSlova
Alzheimer´s disease; acetylcholine release; amyloid
n5:klicoveSlovo
n6:Alzheimer%C2%B4s%20disease n6:acetylcholine%20release n6:amyloid
n5:kodStatuVydavatele
US - Spojené státy americké
n5:kontrolniKodProRIV
[28A37C628E56]
n5:nazevZdroje
Neurobiology of Disease
n5:obor
n18:CE
n5:pocetDomacichTvurcuVysledku
4
n5:pocetTvurcuVysledku
6
n5:projekt
n14:IAA500110703 n14:LC554
n5:rokUplatneniVysledku
n8:2010
n5:svazekPeriodika
38
n5:tvurceVysledku
Koivisto, H. Smyčková, Helena Machová, Eva Rudajev, Vladimír Doležal, Vladimír Tanila, H.
n5:wos
275812700004
n5:zamer
n13:AV0Z50110509
s:issn
0969-9961
s:numberOfPages
9