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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F10%3A00343342%21RIV11-GA0-67985823
rdf:type
n17:Vysledek skos:Concept
dcterms:description
The overexpression of pertussis toxin (PTX)-sensitive inhibitory G-proteins (Gi) participating in the development and maintenance of high BP in SHRs suggested us to study Gi-protein involvement in the pathway through which noradrenergic vasoconstriction and calcium influx can be coupled. PTX pretreatment of SHRs significantly decreased BP and reduced sympathetic vasoconstriction, which was partially substituted by enhanced angiotensin II-dependent vasoconstriction. PTX pretreatment of SHRs also decreased BP component sensitive to acute blockade of calcium entry by nifedipine. Thus the enhanced contribution of SNS to hypertension maintenance in SHRs is mediated by Gi-protein-coupled pathway controlling calcium influx through L type of voltage-dependent calcium channels The overexpression of pertussis toxin (PTX)-sensitive inhibitory G-proteins (Gi) participating in the development and maintenance of high BP in SHRs suggested us to study Gi-protein involvement in the pathway through which noradrenergic vasoconstriction and calcium influx can be coupled. PTX pretreatment of SHRs significantly decreased BP and reduced sympathetic vasoconstriction, which was partially substituted by enhanced angiotensin II-dependent vasoconstriction. PTX pretreatment of SHRs also decreased BP component sensitive to acute blockade of calcium entry by nifedipine. Thus the enhanced contribution of SNS to hypertension maintenance in SHRs is mediated by Gi-protein-coupled pathway controlling calcium influx through L type of voltage-dependent calcium channels
dcterms:title
Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin
skos:prefLabel
Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin Role of nifedipine-sensitive sympathetic vasoconstriction in maintenance of high blood pressure in spontaneously hypertensive rats: effect of Gi-protein inactivation by pertussis toxin
skos:notation
RIV/67985823:_____/10:00343342!RIV11-GA0-67985823
n3:aktivita
n9:Z n9:P
n3:aktivity
P(1M0510), P(GA305/08/0139), P(IAA500110902), Z(AV0Z50110509)
n3:cisloPeriodika
5
n3:dodaniDat
n10:2011
n3:domaciTvurceVysledku
n4:4463404 n4:1477498 n4:1413201 n4:2115557
n3:druhVysledku
n16:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
285732
n3:idVysledku
RIV/67985823:_____/10:00343342
n3:jazykVysledku
n15:eng
n3:klicovaSlova
calcium channels; inhibitory G proteins; pertussis toxin
n3:klicoveSlovo
n14:calcium%20channels n14:pertussis%20toxin n14:inhibitory%20G%20proteins
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[88E552EAB511]
n3:nazevZdroje
Journal of Hypertension
n3:obor
n12:FA
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n5:1M0510 n5:GA305%2F08%2F0139 n5:IAA500110902
n3:rokUplatneniVysledku
n10:2010
n3:svazekPeriodika
28
n3:tvurceVysledku
Karen, Petr Zicha, Josef Pintérová, Mária Kuneš, Jaroslav
n3:wos
276706500015
n3:zamer
n11:AV0Z50110509
s:issn
0263-6352
s:numberOfPages
10