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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F09%3A00328539%21RIV10-MSM-67985823
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Cognitive impairment has been found across all subtypes of schizophrenia. The location and function of dopamine-1 receptors (D1Rs) make them attractive targets for the treatment of cognitive impairment in schizophrenia. We investigate the systemic effect of a D1R agonist (A77636) and antagonist (SCH 23390) on hyperlocomotor activity and cognitive deficit induced by an NMDA receptor antagonist (MK-801). Administration of the D1R antagonist had no effect on cognitive function, but decreased hyperlocomotion induced by MK-801. Thus, based on our results, over-activation of D1Rs may exacerbate psychotic symptoms in patients with schizophrenia Cognitive impairment has been found across all subtypes of schizophrenia. The location and function of dopamine-1 receptors (D1Rs) make them attractive targets for the treatment of cognitive impairment in schizophrenia. We investigate the systemic effect of a D1R agonist (A77636) and antagonist (SCH 23390) on hyperlocomotor activity and cognitive deficit induced by an NMDA receptor antagonist (MK-801). Administration of the D1R antagonist had no effect on cognitive function, but decreased hyperlocomotion induced by MK-801. Thus, based on our results, over-activation of D1Rs may exacerbate psychotic symptoms in patients with schizophrenia
dcterms:title
The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats
skos:prefLabel
The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats The effect of a full agonist/antagonist of the D1 receptor on locomotor activity sensorimotor gating and cognitive function in dizocilpine-treated rats
skos:notation
RIV/67985823:_____/09:00328539!RIV10-MSM-67985823
n3:aktivita
n4:Z n4:P
n3:aktivity
P(1M0517), P(GA309/07/0341), P(NR9178), Z(AV0Z50110509), Z(MZ0PCP2005)
n3:cisloPeriodika
7
n3:dodaniDat
n13:2010
n3:domaciTvurceVysledku
n9:2614510 n9:8125023
n3:druhVysledku
n16:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
311977
n3:idVysledku
RIV/67985823:_____/09:00328539
n3:jazykVysledku
n14:eng
n3:klicovaSlova
animal model; cognitive function; D1 receptor
n3:klicoveSlovo
n7:D1%20receptor n7:animal%20model n7:cognitive%20function
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[5EC5FC482114]
n3:nazevZdroje
International Journal of Neuropsychopharmacology
n3:obor
n15:FH
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n12:NR9178 n12:GA309%2F07%2F0341 n12:1M0517
n3:rokUplatneniVysledku
n13:2009
n3:svazekPeriodika
12
n3:tvurceVysledku
Bubeníková-Valešová, V. Svoboda, Jan Horáček, J. Valeš, Karel
n3:wos
268624700002
n3:zamer
n11:MZ0PCP2005 n11:AV0Z50110509
s:issn
1461-1457
s:numberOfPages
11