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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F08%3A00306963%21RIV08-AV0-67985823
rdf:type
skos:Concept n14:Vysledek
dcterms:description
The slowly metabolized proteins of the extracellular matrix, typically collagen and elastin, accumulate reactive metabolites through uncontrolled non-enzymatic reactions such as glycation or the products arising from the reaction of unsaturated long chain fatty acid metabolites (possessing aldehydic groups). A typical example of these non-enzymatic changes is the formation of advanced glycation end-products (AGEs), resulting from the reaction of carbohydrates with the free amino group of proteins. Chronic (three-week) hyperglycemia (resulting from fructose loading) caused a significant increase in pentosidine concentration mainly in the aorta and skin of the three rat strains The slowly metabolized proteins of the extracellular matrix, typically collagen and elastin, accumulate reactive metabolites through uncontrolled non-enzymatic reactions such as glycation or the products arising from the reaction of unsaturated long chain fatty acid metabolites (possessing aldehydic groups). A typical example of these non-enzymatic changes is the formation of advanced glycation end-products (AGEs), resulting from the reaction of carbohydrates with the free amino group of proteins. Chronic (three-week) hyperglycemia (resulting from fructose loading) caused a significant increase in pentosidine concentration mainly in the aorta and skin of the three rat strains Pomalu metabolizující proteiny, např. kolagen a elastin akumulují reaktivní metabolity, vznikající ne-enzymatickými reakcemi např. glykací. Typickým příkladem těchto neenzymatických změn je tvorba pokročilých glykačních produktů (AGEs), vznikajících reakcí cukrů s volnou amino skupinou proteinů. Chronická hyperglykémie zapříčinila výrazné zvýšení koncentrace pentosidinu zejména v aortě a kůži tří kmenů potkanů
dcterms:title
Pentosidin, produkt pokročilé glykace, hromadící se v různých tkáních potkanů s vysokou hladinou fruktózy Advanced glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake Advanced glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake
skos:prefLabel
Pentosidin, produkt pokročilé glykace, hromadící se v různých tkáních potkanů s vysokou hladinou fruktózy Advanced glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake Advanced glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake
skos:notation
RIV/67985823:_____/08:00306963!RIV08-AV0-67985823
n3:strany
89;94
n3:aktivita
n11:Z n11:P
n3:aktivity
P(1M0510), P(GA203/05/2539), P(GA305/08/0108), Z(AV0Z50110509)
n3:cisloPeriodika
1
n3:dodaniDat
n9:2008
n3:domaciTvurceVysledku
n12:2607514 n12:8462852 n12:1477498 n12:3220184 n12:4463404
n3:druhVysledku
n7:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
354985
n3:idVysledku
RIV/67985823:_____/08:00306963
n3:jazykVysledku
n16:eng
n3:klicovaSlova
collagen; pentosidine; ages
n3:klicoveSlovo
n4:pentosidine n4:ages n4:collagen
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[209E3FFFBF63]
n3:nazevZdroje
Physiological Research
n3:obor
n15:CE
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n13:GA203%2F05%2F2539 n13:GA305%2F08%2F0108 n13:1M0510
n3:rokUplatneniVysledku
n9:2008
n3:svazekPeriodika
57
n3:tvurceVysledku
Kuneš, Jaroslav Eckhardt, Adam Zicha, Josef Mikšík, Ivan Mikulíková, Kateřina
n3:zamer
n6:AV0Z50110509
s:issn
0862-8408
s:numberOfPages
6