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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F03%3A20030014%21RIV%2F2004%2FMSM%2FA20004%2FN
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Low-density membrane fragments (domains) were separated from the bulk plasma membranes of HEK293 cells expressing DOP receptor-Gi1alpha fusion protein by drastic homogenization and flotation on sucrose density gradient. Low-density domains exhibited four times higher agonist-stimulated GTPase activity and GTPgammaS binding than the bulk plasma membranes (when corrected for expression levels of the receptor). RGS1 enhanced further the G protein functional activity but did not remove the difference between domain-bound and plasma membrane pools of G protein. By contrast, detergent-extraction of membrane domains diminished functional coupling between G proteinůcoupled receptor and corresponding G protein. Low-density membrane fragments (domains) were separated from the bulk plasma membranes of HEK293 cells expressing DOP receptor-Gi1alpha fusion protein by drastic homogenization and flotation on sucrose density gradient. Low-density domains exhibited four times higher agonist-stimulated GTPase activity and GTPgammaS binding than the bulk plasma membranes (when corrected for expression levels of the receptor). RGS1 enhanced further the G protein functional activity but did not remove the difference between domain-bound and plasma membrane pools of G protein. By contrast, detergent-extraction of membrane domains diminished functional coupling between G proteinůcoupled receptor and corresponding G protein.
dcterms:title
Delta-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains. Delta-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains.
skos:prefLabel
Delta-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains. Delta-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains.
skos:notation
RIV/67985823:_____/03:20030014!RIV/2004/MSM/A20004/N
n3:strany
34;49
n3:aktivita
n9:Z n9:P
n3:aktivity
P(GA309/01/0255), P(LN00A026), Z(AV0Z5011922), Z(MSM 113100003)
n3:cisloPeriodika
1
n3:dodaniDat
n18:2004
n3:domaciTvurceVysledku
n7:1409905 n7:6324215 n7:8184658 n7:3710769 n7:7326718 n7:1925865
n3:druhVysledku
n13:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
603023
n3:idVysledku
RIV/67985823:_____/03:20030014
n3:jazykVysledku
n8:eng
n3:klicovaSlova
membrane domains; GTPase activity; G protein coupling
n3:klicoveSlovo
n15:G%20protein%20coupling n15:GTPase%20activity n15:membrane%20domains
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[1ED3B5F0F943]
n3:nazevZdroje
Journal of Neurochemistry
n3:obor
n14:CE
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
8
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n11:LN00A026 n11:GA309%2F01%2F0255
n3:rokUplatneniVysledku
n18:2003
n3:svazekPeriodika
85
n3:tvurceVysledku
Moon, H. E. Novotný, Jiří Svoboda, Petr Bouřová, Lenka Koštrnová, Alexandra Hejnová, Lucie Milligan, G. Moravcová, Zuzana
n3:zamer
n10:AV0Z5011922 n10:MSM%20113100003
s:issn
0022-3042
s:numberOfPages
16