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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F02%3A20020057%21RIV%2F2003%2FGA0%2FA20003%2FN
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Adaptation of rats to chronic hypoxia increases the tolerance of their hearts to acute ischemia/reperfusion injury. Administration of a selective blocker of mitochondrial ATP sensitive potassium channels (KATP) 5-hydroxydecanoate abolished cardioprotective effects of chronic hypoxia; administration of selective KATP channels openers (diazoxide and BMS 191095) induced protection in normoxic hearts and but did not influence hypoxic heart. The results suggest that opening of mitochondrial KATP channels is involved in the cardioprotective mechanism conferred by long-term adaptation to chronic hypoxia. Adaptation of rats to chronic hypoxia increases the tolerance of their hearts to acute ischemia/reperfusion injury. Administration of a selective blocker of mitochondrial ATP sensitive potassium channels (KATP) 5-hydroxydecanoate abolished cardioprotective effects of chronic hypoxia; administration of selective KATP channels openers (diazoxide and BMS 191095) induced protection in normoxic hearts and but did not influence hypoxic heart. The results suggest that opening of mitochondrial KATP channels is involved in the cardioprotective mechanism conferred by long-term adaptation to chronic hypoxia.
dcterms:title
Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats. Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats.
skos:prefLabel
Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats. Effects of mitochondrial KATP modulators on cardioprotection induced by chronic high altitude hypoxia in rats.
skos:notation
RIV/67985823:_____/02:20020057!RIV/2003/GA0/A20003/N
n3:strany
567;575
n3:aktivita
n16:P n16:Z
n3:aktivity
P(GA305/01/0279), P(GA306/98/0470), P(LN00A069), Z(AV0Z5011922)
n3:cisloPeriodika
3
n3:dodaniDat
n6:2003
n3:domaciTvurceVysledku
n4:2851601 n4:9825444 n4:7549881 n4:2417480 n4:2972271
n3:druhVysledku
n14:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
644433
n3:idVysledku
RIV/67985823:_____/02:20020057
n3:jazykVysledku
n9:eng
n3:klicovaSlova
contractile function; hypoxia/anoxia; K-ATP channel
n3:klicoveSlovo
n13:contractile%20function n13:K-ATP%20channel n13:hypoxia%2Fanoxia
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[E0AFAF37E32B]
n3:nazevZdroje
Cardiovascular Research
n3:obor
n15:ED
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
7
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n7:LN00A069 n7:GA306%2F98%2F0470 n7:GA305%2F01%2F0279
n3:rokUplatneniVysledku
n6:2002
n3:svazekPeriodika
55
n3:tvurceVysledku
Grover, G. J. Papoušek, František Koten, L. Neckář, Jan Ošťádal, Bohuslav Szárszoi, Ondrej Kolář, František
n3:zamer
n17:AV0Z5011922
s:issn
0008-6363
s:numberOfPages
9