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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F01%3A20010183%21RIV%2F2003%2FAV0%2FA20003%2FN
rdf:type
skos:Concept n14:Vysledek
dcterms:description
This study provides direct evidence that a gene or genes on chromosome Y contribute to the pathogenesis of spontaneous hypertension in the SHR strain. It was also demonstrated that transfer of the Y chromosome from the BN rat onto the SHR background exacerbates dietary-induced dyslipidemia in SHR. Thus, genetic variation in genes on the Y chromosome may contribute to variation in blood pressure and lipid levels and may influence the risk for cardiovascular disease. This study provides direct evidence that a gene or genes on chromosome Y contribute to the pathogenesis of spontaneous hypertension in the SHR strain. It was also demonstrated that transfer of the Y chromosome from the BN rat onto the SHR background exacerbates dietary-induced dyslipidemia in SHR. Thus, genetic variation in genes on the Y chromosome may contribute to variation in blood pressure and lipid levels and may influence the risk for cardiovascular disease.
dcterms:title
Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR. Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR.
skos:prefLabel
Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR. Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR.
skos:notation
RIV/67985823:_____/01:20010183!RIV/2003/AV0/A20003/N
n4:strany
1147;1152
n4:aktivita
n6:Z n6:P
n4:aktivity
P(GA305/00/1646), P(GV204/98/K015), Z(AV0Z5011922)
n4:cisloPeriodika
4
n4:dodaniDat
n8:2003
n4:domaciTvurceVysledku
n10:1168207 n10:9889140 n10:2062402
n4:druhVysledku
n13:J
n4:duvernostUdaju
n9:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
702372
n4:idVysledku
RIV/67985823:_____/01:20010183
n4:jazykVysledku
n18:eng
n4:klicovaSlova
genetic hypertension; - spontaneously hypertensive rats; - cardiovascular disease
n4:klicoveSlovo
n7:-%20cardiovascular%20disease n7:-%20spontaneously%20hypertensive%20rats n7:genetic%20hypertension
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[937443649547]
n4:nazevZdroje
Hypertension
n4:obor
n16:EB
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
14
n4:pocetUcastnikuAkce
0
n4:pocetZahranicnichUcastnikuAkce
0
n4:projekt
n12:GA305%2F00%2F1646 n12:GV204%2F98%2FK015
n4:rokUplatneniVysledku
n8:2001
n4:svazekPeriodika
37
n4:tvurceVysledku
St. Lezin, E. Jáchymová, M. Sladká, M. Van Lith, H. A. Pravenec, Michal Qi, N. Bonne, A. Míková, B. Křen, Vladimír Van Zutphen, B. F. Lau, Y. F. C. Horký, K. Křenová, D. Zídek, Václav
n4:zamer
n11:AV0Z5011922
s:issn
0194-911X
s:numberOfPages
6