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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F01%3A20010171%21RIV%2F2003%2FAV0%2FA20003%2FN
rdf:type
skos:Concept n18:Vysledek
dcterms:description
We found that in SHR harboring the deletion variant of Cd36 (fatty acid transporter), transgenic expression of wild type Cd36 in modest amounts ameliorates defects in fatty acid metabolism, glucose tolerance, and insulin stimulated glucose uptake in muscle and fat tissue and second, exerts little or no effect on blood pressure. In conclusion, the current studies provide definitive evidence that mutant Cd36 is a QTL with major effect on insulin action, glucose tolerance, and serum fatty acid levels in the SHR/NIH strains. We found that in SHR harboring the deletion variant of Cd36 (fatty acid transporter), transgenic expression of wild type Cd36 in modest amounts ameliorates defects in fatty acid metabolism, glucose tolerance, and insulin stimulated glucose uptake in muscle and fat tissue and second, exerts little or no effect on blood pressure. In conclusion, the current studies provide definitive evidence that mutant Cd36 is a QTL with major effect on insulin action, glucose tolerance, and serum fatty acid levels in the SHR/NIH strains.
dcterms:title
Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats. Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats.
skos:prefLabel
Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats. Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats.
skos:notation
RIV/67985823:_____/01:20010171!RIV/2003/AV0/A20003/N
n3:strany
156;158
n3:aktivita
n13:P n13:Z
n3:aktivity
P(GA301/00/1636), P(GV204/98/K015), P(LN00A079), Z(AV0Z5011922), Z(AV0Z5052915)
n3:cisloPeriodika
2
n3:dodaniDat
n15:2003
n3:domaciTvurceVysledku
n6:9889140 n6:1168207 n6:2062402 n6:1559311
n3:druhVysledku
n14:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
699047
n3:idVysledku
RIV/67985823:_____/01:20010171
n3:jazykVysledku
n4:eng
n3:klicovaSlova
Cd36 (fatty acid transporter)
n3:klicoveSlovo
n12:Cd36%20%28fatty%20acid%20transporter%29
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[2693F32151D4]
n3:nazevZdroje
Nature Genetics
n3:obor
n9:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
14
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n7:GV204%2F98%2FK015 n7:GA301%2F00%2F1636 n7:LN00A079
n3:rokUplatneniVysledku
n15:2001
n3:svazekPeriodika
27
n3:tvurceVysledku
Kurtz, T. W. St. Lezin, E. M. Kazdová, L. Glazier, A. M. Landa, Vladimír Abumrad, N. A. Křen, Vladimír Zídek, Václav Qi, N. Musilová, Alena Aitman, T. J. Pravenec, Michal Wang, J. M. Ibrahimi, A.
n3:zamer
n8:AV0Z5011922 n8:AV0Z5052915
s:issn
1061-4036
s:numberOfPages
3