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Statements

Subject Item
n2:RIV%2F67985823%3A_____%2F01%3A00000073%21RIV%2F2005%2FAV0%2FA20005%2FN
rdf:type
n11:Vysledek skos:Concept
dcterms:description
It was found that in SHR harboring the deletion variant of Cd36, transgenic expression of wild type Cd36 in modest amounts ameliorated defects in fatty acid metabolism, glucose tolerance, and insulin stimulated glucose uptake in muscle and fat tissue, however, exerted little or no effect on blood pressure. In conclusion, the current studies provided definitive evidence that mutant Cd36 is a QTL with major effects on fatty acid metabolism, insulin action, and glucose tolerance but have no effects on spontaneous hypertension in the SHR/NIH strains Pomocí kombinace vazebných analýz, analýz kongenních kmenů, studia profilů genové exprese a komplementačních studií pomocí transgeneze, jsme odhalili deleční mutaci genu Cd36 jako primární příčinu metabolických poruch u kmene SHR It was found that in SHR harboring the deletion variant of Cd36, transgenic expression of wild type Cd36 in modest amounts ameliorated defects in fatty acid metabolism, glucose tolerance, and insulin stimulated glucose uptake in muscle and fat tissue, however, exerted little or no effect on blood pressure. In conclusion, the current studies provided definitive evidence that mutant Cd36 is a QTL with major effects on fatty acid metabolism, insulin action, and glucose tolerance but have no effects on spontaneous hypertension in the SHR/NIH strains
dcterms:title
Odhalení defektního CD36 jako lokusu kvantitativních znaků podmiňujícího koincidenci kardiovaskulárních rizikových faktorů u spontánně hypertenzních potkanů Identification of defective CD36 as a quantitative trait locus for cardiovascular risk factor clustering in the spontaneously hypertensive rat Identification of defective CD36 as a quantitative trait locus for cardiovascular risk factor clustering in the spontaneously hypertensive rat
skos:prefLabel
Identification of defective CD36 as a quantitative trait locus for cardiovascular risk factor clustering in the spontaneously hypertensive rat Identification of defective CD36 as a quantitative trait locus for cardiovascular risk factor clustering in the spontaneously hypertensive rat Odhalení defektního CD36 jako lokusu kvantitativních znaků podmiňujícího koincidenci kardiovaskulárních rizikových faktorů u spontánně hypertenzních potkanů
skos:notation
RIV/67985823:_____/01:00000073!RIV/2005/AV0/A20005/N
n3:strany
161;169
n3:aktivita
n6:P n6:Z
n3:aktivity
P(GA301/00/1636), P(GA305/00/1646), P(GV204/98/K015), P(LN00A079), Z(AV0Z5011922)
n3:cisloPeriodika
2
n3:dodaniDat
n14:2005
n3:domaciTvurceVysledku
n4:9889140 n4:2062402 n4:1168207 n4:9002553
n3:druhVysledku
n7:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
682270
n3:idVysledku
RIV/67985823:_____/01:00000073
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Cd36 (fatty acid transporter);spontaneously hypertensive rat
n3:klicoveSlovo
n5:spontaneously%20hypertensive%20rat n5:Cd36%20%28fatty%20acid%20transporter%29
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[14B0274B1D1B]
n3:nazevZdroje
Current Genomics
n3:obor
n16:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n12:GA305%2F00%2F1646 n12:GA301%2F00%2F1636 n12:LN00A079 n12:GV204%2F98%2FK015
n3:rokUplatneniVysledku
n14:2001
n3:svazekPeriodika
2
n3:tvurceVysledku
Zídek, Václav Landa, Vladimír Křen, Vladimír Pravenec, Michal
n3:zamer
n15:AV0Z5011922
s:issn
1389-2029
s:numberOfPages
9