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Statements

Subject Item
n2:RIV%2F67985807%3A_____%2F12%3A00383760%21RIV13-AV0-67985807
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Cardiovascular disease, while rare in women of reproductive age, is the main cause of mortality in menopause. The purpose of our study was to determine the association of natural menopause with cardiovascular risk factors, including their clustering into metabolic syndrome (MS). A random 5% representative population sample of women aged 45-54 years was examined. In 575 women, we were able to determine their natural reproductive aging status. Multiple regression analysis was used to calculate the association between age, menopausal status, and risk factors under study. After adjustment for age, there was an increase in the odds ratio of developing MS, as defined by NCEP (OR=2.0; 95% CI [1.1; 3.7]), and an increase in plasma lipid ratios (total cholesterol/HDL-C, LDL-C/HDL-C, apolipoprotein-B/apolipoprotein-A1; p<0.05 for all) in postmenopausal women. Age, but not menopausal status, was associated with some single components of MS; only waist circumference significantly increased after menopause, independently of age. Clustering of risk factors in MS and lipid ratios (combined factors) was strongly associated with menopause whereas worsening of single components of MS was strongly associated with age. In conclusion, based on our results, the menopause may pose a risk to women through clustering of cardiovascular risk factors beyond simple aging. Cardiovascular disease, while rare in women of reproductive age, is the main cause of mortality in menopause. The purpose of our study was to determine the association of natural menopause with cardiovascular risk factors, including their clustering into metabolic syndrome (MS). A random 5% representative population sample of women aged 45-54 years was examined. In 575 women, we were able to determine their natural reproductive aging status. Multiple regression analysis was used to calculate the association between age, menopausal status, and risk factors under study. After adjustment for age, there was an increase in the odds ratio of developing MS, as defined by NCEP (OR=2.0; 95% CI [1.1; 3.7]), and an increase in plasma lipid ratios (total cholesterol/HDL-C, LDL-C/HDL-C, apolipoprotein-B/apolipoprotein-A1; p<0.05 for all) in postmenopausal women. Age, but not menopausal status, was associated with some single components of MS; only waist circumference significantly increased after menopause, independently of age. Clustering of risk factors in MS and lipid ratios (combined factors) was strongly associated with menopause whereas worsening of single components of MS was strongly associated with age. In conclusion, based on our results, the menopause may pose a risk to women through clustering of cardiovascular risk factors beyond simple aging.
dcterms:title
Natural postmenopause is associated with an increase in combined cardiovascular risk factors Natural postmenopause is associated with an increase in combined cardiovascular risk factors
skos:prefLabel
Natural postmenopause is associated with an increase in combined cardiovascular risk factors Natural postmenopause is associated with an increase in combined cardiovascular risk factors
skos:notation
RIV/67985807:_____/12:00383760!RIV13-AV0-67985807
n6:predkladatel
n7:ico%3A67985807
n3:aktivita
n11:P n11:Z
n3:aktivity
P(NS10511), Z(AV0Z10300504)
n3:cisloPeriodika
6
n3:dodaniDat
n9:2013
n3:domaciTvurceVysledku
n16:6423205
n3:druhVysledku
n5:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
153204
n3:idVysledku
RIV/67985807:_____/12:00383760
n3:jazykVysledku
n15:eng
n3:klicovaSlova
menopause; metabolic syndrome; dyslipidemia; cardiovascular disease; central obesity
n3:klicoveSlovo
n4:menopause n4:metabolic%20syndrome n4:central%20obesity n4:dyslipidemia n4:cardiovascular%20disease
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[3887116F65E0]
n3:nazevZdroje
Physiological Research
n3:obor
n13:FB
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
5
n3:projekt
n14:NS10511
n3:rokUplatneniVysledku
n9:2012
n3:svazekPeriodika
61
n3:tvurceVysledku
Adámková, S. Lejsková, M. Alušík, Š. Valenta, Zdeněk Piťha, J.
n3:wos
000314138600004
n3:zamer
n18:AV0Z10300504
s:issn
0862-8408
s:numberOfPages
10