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Statements

Subject Item
n2:RIV%2F67985807%3A_____%2F12%3A00369644%21RIV13-AV0-67985807
rdf:type
n7:Vysledek skos:Concept
dcterms:description
The aim of this study was to confirm the immunoregulatory and anti-inflammatory changes in the immunologic profile after two months of the facilitation physiotherapy in patients with multiple sclerosis (MS); and to determine whether the changes in the immunologic profile correlate with the changes in dehydroepiandrosterone, the brain microstructure and clinical functions. A group of 12 MS patients was examined twice: at the beginning and 2 months later after the patients had undergone the facilitation therapy. Standardized tests evaluating chosen clinical functions (balance, righting, equilibrium and protective reactions, tremor, dysdiadochokinesis, dysmetry, fine hand function and walking), immune parameters (parameters of the humoral and cellular immunity), dehydroepiandrosterone and diffusion tensor imaging (the fractional anisotropy, mean diffusivity) were measured. The patients underwent the facilitation physiotherapy in two sessions lasting two hours each week for two months. All clinical and diffusion tensor imaging parameters significantly improved following the therapy. Without the correction for multiple comparisons, there were significant changes in the IgG, IgG1 subclasses, in the numbers of Neutrophils and Lymphocytes, the T cells (CD3+) absolute number, the T cytotoxic subpopulation (CD3+CD8+) absolute number, B cells (CD19+) and the Natural killer cells. In addition, there was a significant correlation between the changes in the clinical functions and the changes in IgG1, and between the changes in the mean diffusivity and the changes in CD3+CD8+ absolute. The changes in the immune parameters and the mentioned correlations were not significant in view of the number of comparisons and thus necessitate further validation. No changes in the dehydroepiandrosterone concentration after the therapy were confirmed. The study suggests new possibilities of physiotherapy to influence the psycho–neuro–endocrine– immune response in MS patients. The aim of this study was to confirm the immunoregulatory and anti-inflammatory changes in the immunologic profile after two months of the facilitation physiotherapy in patients with multiple sclerosis (MS); and to determine whether the changes in the immunologic profile correlate with the changes in dehydroepiandrosterone, the brain microstructure and clinical functions. A group of 12 MS patients was examined twice: at the beginning and 2 months later after the patients had undergone the facilitation therapy. Standardized tests evaluating chosen clinical functions (balance, righting, equilibrium and protective reactions, tremor, dysdiadochokinesis, dysmetry, fine hand function and walking), immune parameters (parameters of the humoral and cellular immunity), dehydroepiandrosterone and diffusion tensor imaging (the fractional anisotropy, mean diffusivity) were measured. The patients underwent the facilitation physiotherapy in two sessions lasting two hours each week for two months. All clinical and diffusion tensor imaging parameters significantly improved following the therapy. Without the correction for multiple comparisons, there were significant changes in the IgG, IgG1 subclasses, in the numbers of Neutrophils and Lymphocytes, the T cells (CD3+) absolute number, the T cytotoxic subpopulation (CD3+CD8+) absolute number, B cells (CD19+) and the Natural killer cells. In addition, there was a significant correlation between the changes in the clinical functions and the changes in IgG1, and between the changes in the mean diffusivity and the changes in CD3+CD8+ absolute. The changes in the immune parameters and the mentioned correlations were not significant in view of the number of comparisons and thus necessitate further validation. No changes in the dehydroepiandrosterone concentration after the therapy were confirmed. The study suggests new possibilities of physiotherapy to influence the psycho–neuro–endocrine– immune response in MS patients.
dcterms:title
Physiotherapy as an immunoactive therapy? A pilot study Physiotherapy as an immunoactive therapy? A pilot study
skos:prefLabel
Physiotherapy as an immunoactive therapy? A pilot study Physiotherapy as an immunoactive therapy? A pilot study
skos:notation
RIV/67985807:_____/12:00369644!RIV13-AV0-67985807
n7:predkladatel
n15:ico%3A67985807
n3:aktivita
n14:Z n14:I n14:P
n3:aktivity
I, P(1M06014), Z(AV0Z10300504)
n3:cisloPeriodika
1
n3:dodaniDat
n5:2013
n3:domaciTvurceVysledku
n13:1960172 n13:1071130
n3:druhVysledku
n17:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
158676
n3:idVysledku
RIV/67985807:_____/12:00369644
n3:jazykVysledku
n18:eng
n3:klicovaSlova
multiple sclerosis; physiotherapy; facilitation; humoral and cellular immunity; immunomodulation; dehydroepiandrosterone
n3:klicoveSlovo
n10:immunomodulation n10:facilitation n10:humoral%20and%20cellular%20immunity n10:multiple%20sclerosis n10:dehydroepiandrosterone n10:physiotherapy
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[725D4ADB0686]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n6:EC
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
13
n3:projekt
n19:1M06014
n3:rokUplatneniVysledku
n5:2012
n3:svazekPeriodika
33
n3:tvurceVysledku
Tintěra, J. Doležil, D. Zvára, Karel Martinková, Patrícia Juzová, O. Kučera, P. Zimová, D. Bičíková, M. Řasová, K. Ibrahim, I. Medová, E. Kalistová, H. Jandová, D.
n3:zamer
n12:AV0Z10300504
s:issn
0172-780X
s:numberOfPages
9