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Statements

Subject Item
n2:RIV%2F67985807%3A_____%2F10%3A00343468%21RIV11-AV0-67985807
rdf:type
n11:Vysledek skos:Concept
dcterms:description
There is accumulating evidence that disturbances in N-methyl-D-aspartate receptor (NMDA-R) functioning are associated with the pathogenesis of schizophrenia. To assess actual changes in the expression of the GluN1 subunit and its isoforms, we measured absolute differences in the levels of mRNA/protein for panGluN1 (eight isoforms altogether) as well as the mRNA individual isoforms in the postmortem left/right hippocampus of patients with schizophrenia in comparison with non-psychiatric subjects. Our results suggest that NMDA-R hypofunction in schizophrenia might be selectively dependent on the dysregulation of GluN1 subunit expression, which exhibits a somewhat different expression in the left/right hippocampus of psychotic patients. There is accumulating evidence that disturbances in N-methyl-D-aspartate receptor (NMDA-R) functioning are associated with the pathogenesis of schizophrenia. To assess actual changes in the expression of the GluN1 subunit and its isoforms, we measured absolute differences in the levels of mRNA/protein for panGluN1 (eight isoforms altogether) as well as the mRNA individual isoforms in the postmortem left/right hippocampus of patients with schizophrenia in comparison with non-psychiatric subjects. Our results suggest that NMDA-R hypofunction in schizophrenia might be selectively dependent on the dysregulation of GluN1 subunit expression, which exhibits a somewhat different expression in the left/right hippocampus of psychotic patients.
dcterms:title
Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study
skos:prefLabel
Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study
skos:notation
RIV/67985807:_____/10:00343468!RIV11-AV0-67985807
n4:aktivita
n6:P n6:V n6:Z
n4:aktivity
P(NR9324), V, Z(AV0Z10300504), Z(AV0Z50110509), Z(MZ0PCP2005)
n4:cisloPeriodika
7
n4:dodaniDat
n12:2011
n4:domaciTvurceVysledku
n5:8833826
n4:druhVysledku
n18:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
258530
n4:idVysledku
RIV/67985807:_____/10:00343468
n4:jazykVysledku
n9:eng
n4:klicovaSlova
schizophrenia; hippocampus; GluN1 subunit of NMDA receptor; splice variants; laterality
n4:klicoveSlovo
n14:laterality n14:GluN1%20subunit%20of%20NMDA%20receptor n14:schizophrenia n14:hippocampus n14:splice%20variants
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[13CF9E683B9F]
n4:nazevZdroje
Neurochemical Research
n4:obor
n8:FL
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
8
n4:projekt
n15:NR9324
n4:rokUplatneniVysledku
n12:2010
n4:svazekPeriodika
35
n4:tvurceVysledku
Šťastný, František Höschl, C. Klaschka, Jan Horáček, J. Peková, S. Vrajová, M. Šerý, O. Lochman, J.
n4:wos
000278411000005
n4:zamer
n7:AV0Z50110509 n7:AV0Z10300504 n7:MZ0PCP2005
s:issn
0364-3190
s:numberOfPages
9