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Statements

Subject Item
n2:RIV%2F65269705%3A_____%2F13%3A%230002213%21RIV14-MZ0-65269705
rdf:type
skos:Concept n11:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.3109/10428194.2013.796058
dcterms:description
The ATM-p53 DNA damage response pathway plays a crucial role in chemoresistance in chronic lymphocytic leukemia, as indicated by the adverse prognostic impact of deletions of 17p (locus of TP53) and 11q (locus of ATM) detected by fluorescence in situ hybridization (FISH) analysis. In addition to deletions, mutations in these respective genes are also associated with chemoresistance, and add to the prognostic information provided by FISH. In order to explore the possibility that dysfunction of the ATM-p53 pathway might also result from mechanisms other than ATM/TP53 deletion/mutation, assays have been developed that probe the functional integrity of the ATM-p53 pathway. Currently, four different p53 function assays have been developed that are based on the measurement of p53 and p53-dependent genes at the RNA (real-time polymerase chain reaction [RT-PCR]p21; RT-PCRmiR34a; reverse transcription-multiplex ligation-dependent probe amplification assay [RT-MLPA]p21, bax, puma and CD95) or protein (fluorescence activated cell sorting [FACS]p53-p21) level in untreated cells or following irradiation or drug treatment. Here we provide an overview of these assays based on the available literature.. The ATM-p53 DNA damage response pathway plays a crucial role in chemoresistance in chronic lymphocytic leukemia, as indicated by the adverse prognostic impact of deletions of 17p (locus of TP53) and 11q (locus of ATM) detected by fluorescence in situ hybridization (FISH) analysis. In addition to deletions, mutations in these respective genes are also associated with chemoresistance, and add to the prognostic information provided by FISH. In order to explore the possibility that dysfunction of the ATM-p53 pathway might also result from mechanisms other than ATM/TP53 deletion/mutation, assays have been developed that probe the functional integrity of the ATM-p53 pathway. Currently, four different p53 function assays have been developed that are based on the measurement of p53 and p53-dependent genes at the RNA (real-time polymerase chain reaction [RT-PCR]p21; RT-PCRmiR34a; reverse transcription-multiplex ligation-dependent probe amplification assay [RT-MLPA]p21, bax, puma and CD95) or protein (fluorescence activated cell sorting [FACS]p53-p21) level in untreated cells or following irradiation or drug treatment. Here we provide an overview of these assays based on the available literature..
dcterms:title
Overview of available p53 function tests in relation to TP53 and ATM gene alterations and chemoresistance in chronic lymphocytic leukemia Overview of available p53 function tests in relation to TP53 and ATM gene alterations and chemoresistance in chronic lymphocytic leukemia
skos:prefLabel
Overview of available p53 function tests in relation to TP53 and ATM gene alterations and chemoresistance in chronic lymphocytic leukemia Overview of available p53 function tests in relation to TP53 and ATM gene alterations and chemoresistance in chronic lymphocytic leukemia
skos:notation
RIV/65269705:_____/13:#0002213!RIV14-MZ0-65269705
n11:predkladatel
n18:ico%3A65269705
n3:aktivita
n15:V n15:I
n3:aktivity
I, V
n3:cisloPeriodika
8
n3:dodaniDat
n10:2014
n3:domaciTvurceVysledku
n13:4629604 n13:1957864 n13:2093995 n13:4382749
n3:druhVysledku
n5:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
95025
n3:idVysledku
RIV/65269705:_____/13:#0002213
n3:jazykVysledku
n4:eng
n3:klicovaSlova
chronic lymphocytic leukemia; DNA damage response; p53 function assays; p53 axis; TP53; ATM
n3:klicoveSlovo
n9:TP53 n9:chronic%20lymphocytic%20leukemia n9:DNA%20damage%20response n9:ATM n9:p53%20axis n9:p53%20function%20assays
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[87401CA101AF]
n3:nazevZdroje
Leukemia & Lymphoma
n3:obor
n19:FD
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
16
n3:rokUplatneniVysledku
n10:2013
n3:svazekPeriodika
54
n3:tvurceVysledku
Trbušek, Martin Mráz, Marek Malčíková, Jitka Pospíšilová, Šárka
n3:wos
000321763800054
s:issn
1042-8194
s:numberOfPages
5
n17:doi
10.3109/10428194.2013.796058