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Statements

Subject Item
n2:RIV%2F65269705%3A_____%2F13%3A%230002135%21RIV14-MZ0-65269705
rdf:type
skos:Concept n6:Vysledek
rdfs:seeAlso
http://dx.doi.org/10.1016/j.jneuroim.2012.10.014
dcterms:description
We investigated the HLA-DRB1*1501 tagging rs3135388 gene polymorphism and its association with multiple sclerosis (MS) susceptibility, disability and gender differences. The study group consisted of 306 MS patients and 137 healthy individuals. A significant difference in genotype distribution (Pg = 3.06 x 10 - 9) and allele frequency (Pa = 6.08 x 10- 10) between MS patients and controls was demonstrated. The homozygotes AA and heterozygotes GA were more frequent in MS patients (OR = 4.27, 95% CI: 2.64-6.92). A significant difference between female MS patients and female controls in genotype distribution (Pg = 1.3 x 10- 8) and allele frequency (Pa = 2.82 x 10- 9); (OR = 5.11, 95% CI: 2.86-9.15) was also proved. Our results indicate that the distribution of the rs3135388 gene polymorphism is a risk factor for MS susceptibility in the Czech female population.. We investigated the HLA-DRB1*1501 tagging rs3135388 gene polymorphism and its association with multiple sclerosis (MS) susceptibility, disability and gender differences. The study group consisted of 306 MS patients and 137 healthy individuals. A significant difference in genotype distribution (Pg = 3.06 x 10 - 9) and allele frequency (Pa = 6.08 x 10- 10) between MS patients and controls was demonstrated. The homozygotes AA and heterozygotes GA were more frequent in MS patients (OR = 4.27, 95% CI: 2.64-6.92). A significant difference between female MS patients and female controls in genotype distribution (Pg = 1.3 x 10- 8) and allele frequency (Pa = 2.82 x 10- 9); (OR = 5.11, 95% CI: 2.86-9.15) was also proved. Our results indicate that the distribution of the rs3135388 gene polymorphism is a risk factor for MS susceptibility in the Czech female population..
dcterms:title
Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis
skos:prefLabel
Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis
skos:notation
RIV/65269705:_____/13:#0002135!RIV14-MZ0-65269705
n6:predkladatel
n7:ico%3A65269705
n4:aktivita
n13:P n13:I
n4:aktivity
I, P(ED1.1.00/02.0068)
n4:cisloPeriodika
1-2
n4:dodaniDat
n12:2014
n4:domaciTvurceVysledku
n11:3501604 n11:3148882
n4:druhVysledku
n14:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n20:predkladatel
n4:idSjednocenehoVysledku
62353
n4:idVysledku
RIV/65269705:_____/13:#0002135
n4:jazykVysledku
n10:eng
n4:klicovaSlova
Gene; HLA-DRB1*1501; Multiple sclerosis; Tagging polymorphism
n4:klicoveSlovo
n5:Tagging%20polymorphism n5:HLA-DRB1%2A1501 n5:Multiple%20sclerosis n5:Gene
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[20A39589A7E0]
n4:nazevZdroje
Journal of neuroimmunology
n4:obor
n18:FH
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
6
n4:projekt
n19:ED1.1.00%2F02.0068
n4:rokUplatneniVysledku
n12:2013
n4:svazekPeriodika
255
n4:tvurceVysledku
Hladíková, Magdalena Benešová, Yvonne
n4:wos
000315014700013
s:issn
0165-5728
s:numberOfPages
5
n16:doi
10.1016/j.jneuroim.2012.10.014