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Statements

Subject Item
n2:RIV%2F65269705%3A_____%2F13%3A%230002085%21RIV14-MZ0-65269705
rdf:type
n3:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1016/j.schres.2013.06.015
dcterms:description
The aim of the study was to assess the effect of rTMS not only on the general severity of negative schizophrenia symptoms, but also particularly on their individual domains, such as affective flattening or blunting, alogia, avolition or apathy, anhedonia, and impaired attention. Methods Forty schizophrenic male patients on stable antipsychotic medication with prominent negative symptoms were included in the study. They were divided into two groups: 23 were treated with active and 17 with placebo rTMS. Both treatments were similar, but placebo rTMS was administered using a purpose-built sham coil. Stimulation was applied to the left dorsolateral prefrontal cortex (DLPFC). The stimulation frequency was 10 Hz; stimulation intensity was 110% of the individual motor threshold intensity. Each patient received 15 rTMS sessions on 15 consecutive working days (five working days “on” and two weekend days “off” design). Each daily session consisted of 20 applications of 10-second duration with 30-second intervals between sequences. The patients and raters were blind to condition of stimulation treatment. Results The active rTMS led to a statistically significantly higher reduction of the Scale for the Assessment of Negative Symptoms (SANS) total score and of all domains of negative symptoms of schizophrenia. After Bonferroni adjustments for multiple testing, the statistical significance disappeared in alogia only. Conclusion High-frequency rTMS stimulation over the left DLPFC at a high stimulation intensity with a sufficient number of applied stimulating pulses may represent an efficient augmentation of antipsychotics in alleviating the negative symptoms of schizophrenia.. The aim of the study was to assess the effect of rTMS not only on the general severity of negative schizophrenia symptoms, but also particularly on their individual domains, such as affective flattening or blunting, alogia, avolition or apathy, anhedonia, and impaired attention. Methods Forty schizophrenic male patients on stable antipsychotic medication with prominent negative symptoms were included in the study. They were divided into two groups: 23 were treated with active and 17 with placebo rTMS. Both treatments were similar, but placebo rTMS was administered using a purpose-built sham coil. Stimulation was applied to the left dorsolateral prefrontal cortex (DLPFC). The stimulation frequency was 10 Hz; stimulation intensity was 110% of the individual motor threshold intensity. Each patient received 15 rTMS sessions on 15 consecutive working days (five working days “on” and two weekend days “off” design). Each daily session consisted of 20 applications of 10-second duration with 30-second intervals between sequences. The patients and raters were blind to condition of stimulation treatment. Results The active rTMS led to a statistically significantly higher reduction of the Scale for the Assessment of Negative Symptoms (SANS) total score and of all domains of negative symptoms of schizophrenia. After Bonferroni adjustments for multiple testing, the statistical significance disappeared in alogia only. Conclusion High-frequency rTMS stimulation over the left DLPFC at a high stimulation intensity with a sufficient number of applied stimulating pulses may represent an efficient augmentation of antipsychotics in alleviating the negative symptoms of schizophrenia..
dcterms:title
A detailed analysis of the effect of repetitive transcranial magnetic stimulation on negative symptoms of schizophrenia: A double-blind trial A detailed analysis of the effect of repetitive transcranial magnetic stimulation on negative symptoms of schizophrenia: A double-blind trial
skos:prefLabel
A detailed analysis of the effect of repetitive transcranial magnetic stimulation on negative symptoms of schizophrenia: A double-blind trial A detailed analysis of the effect of repetitive transcranial magnetic stimulation on negative symptoms of schizophrenia: A double-blind trial
skos:notation
RIV/65269705:_____/13:#0002085!RIV14-MZ0-65269705
n3:predkladatel
n8:ico%3A65269705
n4:aktivita
n7:P n7:I
n4:aktivity
I, P(ED1.1.00/02.0068)
n4:cisloPeriodika
1-3
n4:dodaniDat
n15:2014
n4:domaciTvurceVysledku
n12:4520831 n12:8381305 n12:5303125 n12:6925472 n12:7194447 n12:9175474 n12:3871029
n4:druhVysledku
n20:J
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n14:predkladatel
n4:idSjednocenehoVysledku
58577
n4:idVysledku
RIV/65269705:_____/13:#0002085
n4:jazykVysledku
n10:eng
n4:klicovaSlova
High-frequency; Negative symptoms; Prefrontal cortex; Repetitive transcranial magnetic stimulation; rTMS; SANS
n4:klicoveSlovo
n11:rTMS n11:High-frequency n11:Negative%20symptoms n11:SANS n11:Repetitive%20transcranial%20magnetic%20stimulation n11:Prefrontal%20cortex
n4:kodStatuVydavatele
NL - Nizozemsko
n4:kontrolniKodProRIV
[9C3F8FB0B91B]
n4:nazevZdroje
Schizophrenia Research
n4:obor
n17:FL
n4:pocetDomacichTvurcuVysledku
7
n4:pocetTvurcuVysledku
7
n4:projekt
n19:ED1.1.00%2F02.0068
n4:rokUplatneniVysledku
n15:2013
n4:svazekPeriodika
149
n4:tvurceVysledku
Češková, Eva Venclíková, Simona Ustohal, Libor Vrzalová, Michaela Přikrylová Kučerová, Hana Přikryl, Radovan Kašpárek, Tomáš
n4:wos
000323937200026
s:issn
0920-9964
s:numberOfPages
7
n6:doi
10.1016/j.schres.2013.06.015