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Statements

Subject Item
n2:RIV%2F65269705%3A_____%2F13%3A%230002068%21RIV14-MZ0-65269705
rdf:type
n5:Vysledek skos:Concept
rdfs:seeAlso
http://dx.doi.org/10.1093/bja/aet036
dcterms:description
Myotonic dystrophy is a chronic, slowly progressing, highly variable, inherited multisystemic disease. It is characterized by wasting of the muscles (muscular dystrophy), cataracts, heart conduction abnormalities, endocrine changes, slow gastric and bowel emptying, and myotonia. Patients with myotonic dystrophy show myotonic responses to succinylcholine and neostigmine, and increased sensitivity to non-depolarising muscle relaxants. We report two cases of a parturient with myotonic dystrophy scheduled for Caesarean Section under general anaesthesia, once in 2009 and once in 2011. Muscle relaxant anaesthetic management in 2009 consisted of rocuronium and waiting for spontaneous neuromuscular blockade recovery with arteficial ventilation in the intensive care unit for 2 hours and 30 minutes postoperatively. In 2011, the same patient was indicated for the selective binding agent sugammadex ( 4 mg kg-1) to actively reverse deep neuromuscular blockade at the end of surgery. Train of Four ratio 0.9 was achieved in 2 minutes. There was no exacerbation of myotonia and no recurrence of muscle relaxation perioperatively in either case. These two obstetric cases provide evidence for the benefits of sugammadex in patients with myotonic dystrophy. We also suggest that it could be used in other patients with neuromuscular diseases.. Myotonic dystrophy is a chronic, slowly progressing, highly variable, inherited multisystemic disease. It is characterized by wasting of the muscles (muscular dystrophy), cataracts, heart conduction abnormalities, endocrine changes, slow gastric and bowel emptying, and myotonia. Patients with myotonic dystrophy show myotonic responses to succinylcholine and neostigmine, and increased sensitivity to non-depolarising muscle relaxants. We report two cases of a parturient with myotonic dystrophy scheduled for Caesarean Section under general anaesthesia, once in 2009 and once in 2011. Muscle relaxant anaesthetic management in 2009 consisted of rocuronium and waiting for spontaneous neuromuscular blockade recovery with arteficial ventilation in the intensive care unit for 2 hours and 30 minutes postoperatively. In 2011, the same patient was indicated for the selective binding agent sugammadex ( 4 mg kg-1) to actively reverse deep neuromuscular blockade at the end of surgery. Train of Four ratio 0.9 was achieved in 2 minutes. There was no exacerbation of myotonia and no recurrence of muscle relaxation perioperatively in either case. These two obstetric cases provide evidence for the benefits of sugammadex in patients with myotonic dystrophy. We also suggest that it could be used in other patients with neuromuscular diseases..
dcterms:title
Sugammadex in a parturient with myotonic dystrophy Sugammadex in a parturient with myotonic dystrophy
skos:prefLabel
Sugammadex in a parturient with myotonic dystrophy Sugammadex in a parturient with myotonic dystrophy
skos:notation
RIV/65269705:_____/13:#0002068!RIV14-MZ0-65269705
n5:predkladatel
n20:ico%3A65269705
n3:aktivita
n10:P n10:I
n3:aktivity
I, P(NT13906)
n3:cisloPeriodika
4
n3:dodaniDat
n8:2014
n3:domaciTvurceVysledku
n6:4239350 n6:3574040 n6:6800165 n6:9905065 n6:9711929 n6:6593593 n6:6499201 n6:5874130
n3:druhVysledku
n4:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
108946
n3:idVysledku
RIV/65269705:_____/13:#0002068
n3:jazykVysledku
n11:eng
n3:klicovaSlova
sugammadex; myotonic dystrophyia; Caesarean Section; General Anaesthes
n3:klicoveSlovo
n13:myotonic%20dystrophyia n13:Caesarean%20Section n13:General%20Anaesthes n13:sugammadex
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[0248FA1BA9A4]
n3:nazevZdroje
British Journal of Anaesthesia
n3:obor
n16:FK
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
8
n3:projekt
n18:NT13906
n3:rokUplatneniVysledku
n8:2013
n3:svazekPeriodika
110
n3:tvurceVysledku
Štourač, Petr Gál, Roman Straževská, Eva Hruban, Lukáš Seidlová, Judita Křikava, Ivo Huser, Martin Janků, Petr
n3:wos
000316700600024
s:issn
0007-0912
s:numberOfPages
2
n12:doi
10.1093/bja/aet036