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Statements

Subject Item
n2:RIV%2F65269705%3A_____%2F12%3A%230001845%21RIV13-MZ0-65269705
rdf:type
n12:Vysledek skos:Concept
dcterms:description
Although the role of the non-classical human leukocyte antigen E (HLA-E) was originally thought to be limited to the development of a maternal tolerance to a semiallogeneic fetal graft, it is now known that HLA-E exerts multiple immunoregulatory functions. The significance of the presence of HLA-E in neoplastic cells and/or background microenvironment cells in classical Hodgkin lymphoma (cHL) is not well characterized. In our study, we evaluated the presence of HLA-E in both neoplastic and background cells in 40 cases of cHL. We found HLA-E in both neoplastic and background cells. There was a positive statistical correlation between the expression of HLA-E in neoplastic cells and the clinical stage of the disease, which indicates an immune-tolerogenic property of this multiple-purpose molecule. The presence of HLA-E in background cells seems to be prognostically neutral but its significance still needs to be determined. The mechanisms regulating the immunopathology of cHL neoplastic cells with respect to the presence of these molecule deserve further studies. Although the role of the non-classical human leukocyte antigen E (HLA-E) was originally thought to be limited to the development of a maternal tolerance to a semiallogeneic fetal graft, it is now known that HLA-E exerts multiple immunoregulatory functions. The significance of the presence of HLA-E in neoplastic cells and/or background microenvironment cells in classical Hodgkin lymphoma (cHL) is not well characterized. In our study, we evaluated the presence of HLA-E in both neoplastic and background cells in 40 cases of cHL. We found HLA-E in both neoplastic and background cells. There was a positive statistical correlation between the expression of HLA-E in neoplastic cells and the clinical stage of the disease, which indicates an immune-tolerogenic property of this multiple-purpose molecule. The presence of HLA-E in background cells seems to be prognostically neutral but its significance still needs to be determined. The mechanisms regulating the immunopathology of cHL neoplastic cells with respect to the presence of these molecule deserve further studies.
dcterms:title
Multifunctional immune-modulatory protein HLA-E identified in classical Hodkin lymphoma: Possible implications Multifunctional immune-modulatory protein HLA-E identified in classical Hodkin lymphoma: Possible implications
skos:prefLabel
Multifunctional immune-modulatory protein HLA-E identified in classical Hodkin lymphoma: Possible implications Multifunctional immune-modulatory protein HLA-E identified in classical Hodkin lymphoma: Possible implications
skos:notation
RIV/65269705:_____/12:#0001845!RIV13-MZ0-65269705
n12:predkladatel
n13:ico%3A65269705
n3:aktivita
n16:P
n3:aktivity
P(ED1.1.00/02.0068), P(NS9871)
n3:cisloPeriodika
1
n3:dodaniDat
n8:2013
n3:domaciTvurceVysledku
n5:2975041 n5:5898455 n5:3084000 n5:1398954 n5:7801386 n5:7248857
n3:druhVysledku
n18:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
152348
n3:idVysledku
RIV/65269705:_____/12:#0001845
n3:jazykVysledku
n15:eng
n3:klicovaSlova
hodgkin lymphoma
n3:klicoveSlovo
n19:hodgkin%20lymphoma
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[C0858342FC91]
n3:nazevZdroje
Pathology, research and practice
n3:obor
n6:FD
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
9
n3:projekt
n9:NS9871 n9:ED1.1.00%2F02.0068
n3:rokUplatneniVysledku
n8:2012
n3:svazekPeriodika
208
n3:tvurceVysledku
Křen, Leoš Janíková, Andrea Král, Zdeněk Křenová, Zdeňka Štěrba, Jaroslav Souček, Ondřej
n3:wos
000300602900007
s:issn
0344-0338
s:numberOfPages
5
n10:doi
10.1016/j.prp.2011.11.004