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Statements

Subject Item
n2:RIV%2F65269705%3A_____%2F12%3A%230001666%21RIV13-MZ0-65269705
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0404/earlyview
dcterms:description
Objectives The aim of the study was to evaluate the long-term efficacy and hospitalization rates in children with refractory focal epilepsy treated by vagus nerve stimulation. Materials and methods We retrospectively analyzed 15 children with intractable focal epilepsy treated by vagus nerve stimulation (mean age of 14.6 ± 2.5 years at the time of implantation). We analyzed the treatment effectiveness at 1, 2, and 5 year follow-up visits. We counted the average number of urgent hospitalizations and number of days of urgent hospitalization per year for each patient before and after the VNS implantation. Results The mean seizure reduction was 42.5% at 1 year, 54.9% at 2 years, and 58.3% at 5 years. The number of responders was 7 (46.7%) at 1 year and 9 (60%) at both 2 and 5 years. The mean number of urgent hospitalizations per patient was 1.0 ± 0.6 per year preoperatively and 0.3 ± 0.5 per year post-operatively (P < 0.0001). The mean number of days of urgent hospitalization per patient was 9.3 ± 6.1 per year preoperatively and 1.3 ± 1.8 per year post-operatively (P < 0.0001). Conclusions Vagus nerve stimulation is an effective method of treating children with refractory focal epilepsy. It leads to a substantial decrease in the number and duration of urgent hospitalizations. Objectives The aim of the study was to evaluate the long-term efficacy and hospitalization rates in children with refractory focal epilepsy treated by vagus nerve stimulation. Materials and methods We retrospectively analyzed 15 children with intractable focal epilepsy treated by vagus nerve stimulation (mean age of 14.6 ± 2.5 years at the time of implantation). We analyzed the treatment effectiveness at 1, 2, and 5 year follow-up visits. We counted the average number of urgent hospitalizations and number of days of urgent hospitalization per year for each patient before and after the VNS implantation. Results The mean seizure reduction was 42.5% at 1 year, 54.9% at 2 years, and 58.3% at 5 years. The number of responders was 7 (46.7%) at 1 year and 9 (60%) at both 2 and 5 years. The mean number of urgent hospitalizations per patient was 1.0 ± 0.6 per year preoperatively and 0.3 ± 0.5 per year post-operatively (P < 0.0001). The mean number of days of urgent hospitalization per patient was 9.3 ± 6.1 per year preoperatively and 1.3 ± 1.8 per year post-operatively (P < 0.0001). Conclusions Vagus nerve stimulation is an effective method of treating children with refractory focal epilepsy. It leads to a substantial decrease in the number and duration of urgent hospitalizations.
dcterms:title
Long-term vagus nerve stimulation in childres with focal epilepsy Long-term vagus nerve stimulation in childres with focal epilepsy
skos:prefLabel
Long-term vagus nerve stimulation in childres with focal epilepsy Long-term vagus nerve stimulation in childres with focal epilepsy
skos:notation
RIV/65269705:_____/12:#0001666!RIV13-MZ0-65269705
n10:predkladatel
n19:ico%3A65269705
n5:aktivita
n15:I
n5:aktivity
I
n5:cisloPeriodika
12009
n5:dodaniDat
n9:2013
n5:domaciTvurceVysledku
n6:3588998 n6:8132208 n6:5489660
n5:druhVysledku
n16:J
n5:duvernostUdaju
n7:S
n5:entitaPredkladatele
n17:predkladatel
n5:idSjednocenehoVysledku
147450
n5:idVysledku
RIV/65269705:_____/12:#0001666
n5:jazykVysledku
n18:eng
n5:klicovaSlova
epilepsy
n5:klicoveSlovo
n13:epilepsy
n5:kodStatuVydavatele
DK - Dánské království
n5:kontrolniKodProRIV
[AA4631FC4978]
n5:nazevZdroje
Acta neurologica scandinavica
n5:obor
n11:FH
n5:pocetDomacichTvurcuVysledku
3
n5:pocetTvurcuVysledku
7
n5:rokUplatneniVysledku
n9:2012
n5:svazekPeriodika
2012
n5:tvurceVysledku
Kuba, Robert Ošlejšková, Hana Ryzí, Michal
s:issn
1600-0404
s:numberOfPages
7
n4:doi
10.1111/ane.12009