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Statements

Subject Item
n2:RIV%2F65269705%3A_____%2F11%3A%230001600%21RIV12-MZ0-65269705
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Cancer of endometrium (CAE) is the most common gynecologic malignancy in industrialized nations. Increased resistin levels, an adipocytokine produced by adipose tissue and macrophages, have been considered as a risk factor in gastric, colon and breast cancer, recently. No studies associating resistin levels with endometrial cancer have been done so far. The purpose of this case-control study was to determine the relationship between serum circulating resistin levels and resistin gene -420C>G (rs3219175) variant in endometrial cancer patients. 37 Caucasian female patients and 39 healthy controls were enrolled in this study. Difference in resistin levels between age and BMI matched patients group (mean 24.2 ng/ml) and control subjects (mean 10.1 ng/ml) were statistically significant (p G (rs3219175) within resistin gene and no significant association between resistin levels and investigated polymorphism was found. Furthermore, no significant association between higher resistin levels and diabetes mellitus 2, body mass index, smoking or age have been observed within studied groups. To our knowledge, this is the first study examining the relationship between serum resistin levels and endometrial cancer and our results show, that patients with endometrial cancer have significantly increased circulating levels of resistin compared to control subjects. Cancer of endometrium (CAE) is the most common gynecologic malignancy in industrialized nations. Increased resistin levels, an adipocytokine produced by adipose tissue and macrophages, have been considered as a risk factor in gastric, colon and breast cancer, recently. No studies associating resistin levels with endometrial cancer have been done so far. The purpose of this case-control study was to determine the relationship between serum circulating resistin levels and resistin gene -420C>G (rs3219175) variant in endometrial cancer patients. 37 Caucasian female patients and 39 healthy controls were enrolled in this study. Difference in resistin levels between age and BMI matched patients group (mean 24.2 ng/ml) and control subjects (mean 10.1 ng/ml) were statistically significant (p G (rs3219175) within resistin gene and no significant association between resistin levels and investigated polymorphism was found. Furthermore, no significant association between higher resistin levels and diabetes mellitus 2, body mass index, smoking or age have been observed within studied groups. To our knowledge, this is the first study examining the relationship between serum resistin levels and endometrial cancer and our results show, that patients with endometrial cancer have significantly increased circulating levels of resistin compared to control subjects.
dcterms:title
Relationship of resistin levels with endometrial cancer risk Relationship of resistin levels with endometrial cancer risk
skos:prefLabel
Relationship of resistin levels with endometrial cancer risk Relationship of resistin levels with endometrial cancer risk
skos:notation
RIV/65269705:_____/11:#0001600!RIV12-MZ0-65269705
n10:predkladatel
n13:ico%3A65269705
n5:aktivita
n9:V n9:S
n5:aktivity
S, V
n5:cisloPeriodika
2
n5:dodaniDat
n7:2012
n5:domaciTvurceVysledku
n6:4974786 n6:5521793
n5:druhVysledku
n14:J
n5:duvernostUdaju
n11:S
n5:entitaPredkladatele
n16:predkladatel
n5:idSjednocenehoVysledku
226425
n5:idVysledku
RIV/65269705:_____/11:#0001600
n5:jazykVysledku
n18:eng
n5:klicovaSlova
Endometrial cancer
n5:klicoveSlovo
n12:Endometrial%20cancer
n5:kodStatuVydavatele
SK - Slovenská republika
n5:kontrolniKodProRIV
[E26E51290F54]
n5:nazevZdroje
Neoplasma
n5:obor
n17:FD
n5:pocetDomacichTvurcuVysledku
2
n5:pocetTvurcuVysledku
7
n5:rokUplatneniVysledku
n7:2011
n5:svazekPeriodika
58
n5:tvurceVysledku
Dostálová, Zuzana Chovanec, Josef Hlavna, Marián
n5:wos
000290695700005
s:issn
0028-2685
s:numberOfPages
5
n3:doi
10.4149/neo_2011_02_124