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Statements

Subject Item
n2:RIV%2F65269705%3A_____%2F11%3A%230001395%21RIV12-MZ0-65269705
rdf:type
n10:Vysledek skos:Concept
dcterms:description
The paper provides a basic review of intestinal microflora and its importance in liver diseases. The intestinal microflora has many important functions, above all to maintain the microbial barrier against established as well as potential pathogens. Furthermore, it influences the motility and perfusion of the intestinal wall, stimulates the intestinal immune system and therefore also the so-called common mucosal immune system, reducing bacterial translocation and producing vitamins. Immune homeostasis at mucosal level results from a controlled response to intestinal luminal antigens. In liver cirrhosis, there are many changes in its function, mostly an increase in bacterial overgrowth and translocation. In this review, probiotics and their indications in hepatology are generally discussed. According to recent knowledge, these preparations are indicated in clinical practice only for cases of hepatic encephalopathy. Probiotics are able to decrease the permeability of the intestinal wall, and decrease bacterial translocation and endotoxemia in animal models as well as in clinical studies, which is extremely important in the prevention of complications of liver cirrhosis and infection after liver transplantation. Probiotics could limit oxidative and inflammatory liver damage and, in some situations, improve the histological state, and thus non-alcoholic steatohepatitis could be considered as another possible indication. The paper provides a basic review of intestinal microflora and its importance in liver diseases. The intestinal microflora has many important functions, above all to maintain the microbial barrier against established as well as potential pathogens. Furthermore, it influences the motility and perfusion of the intestinal wall, stimulates the intestinal immune system and therefore also the so-called common mucosal immune system, reducing bacterial translocation and producing vitamins. Immune homeostasis at mucosal level results from a controlled response to intestinal luminal antigens. In liver cirrhosis, there are many changes in its function, mostly an increase in bacterial overgrowth and translocation. In this review, probiotics and their indications in hepatology are generally discussed. According to recent knowledge, these preparations are indicated in clinical practice only for cases of hepatic encephalopathy. Probiotics are able to decrease the permeability of the intestinal wall, and decrease bacterial translocation and endotoxemia in animal models as well as in clinical studies, which is extremely important in the prevention of complications of liver cirrhosis and infection after liver transplantation. Probiotics could limit oxidative and inflammatory liver damage and, in some situations, improve the histological state, and thus non-alcoholic steatohepatitis could be considered as another possible indication.
dcterms:title
Probiotics in hepatology Probiotics in hepatology
skos:prefLabel
Probiotics in hepatology Probiotics in hepatology
skos:notation
RIV/65269705:_____/11:#0001395!RIV12-MZ0-65269705
n10:predkladatel
n11:ico%3A65269705
n3:aktivita
n9:V n9:Z n9:I
n3:aktivity
I, V, Z(MSM6198959223)
n3:cisloPeriodika
24
n3:dodaniDat
n6:2012
n3:domaciTvurceVysledku
n17:3608832
n3:druhVysledku
n16:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
223843
n3:idVysledku
RIV/65269705:_____/11:#0001395
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Intestinal microflora
n3:klicoveSlovo
n8:Intestinal%20microflora
n3:kodStatuVydavatele
CN - Čínská lidová republika
n3:kontrolniKodProRIV
[66ADCB4063CB]
n3:nazevZdroje
World Journal of Gastroenterology
n3:obor
n14:FE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n6:2011
n3:svazekPeriodika
17
n3:tvurceVysledku
Kopáčová, M. Juránková, Jana
n3:wos
000292407100002
n3:zamer
n15:MSM6198959223
s:issn
1007-9327
s:numberOfPages
7
n7:doi
10.3784/wjg.v17.i24.2890