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Statements

Subject Item
n2:RIV%2F65269705%3A_____%2F11%3A%230001275%21RIV12-MZ0-65269705
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Follicular lymphoma (FL) is characterized by an indolent and relapsing course. Recently, the clinical outcome of FL has been distinguished by immune microenvironment-associated gene signatures. In our study, gene expression profiling (GEP) was performed in 31 non-selected patients with follicular lymphoma (FL), 12 of whom were in relapse and the remaining 19 newly diagnosed. A custom oligonucleotide microarray was used which contained probes for about 3500 genes, including those that had been previously published as demonstrating significant prognostic value. An unsupervised approach was not able to recognize clinically different FLs. As the previously published prognostically relevant gene signatures could not be properly verified, probably due to microarray platform differences, template matching was therefore used in order to define two gene sets with differential gene expression among our samples. Follicular lymphoma (FL) is characterized by an indolent and relapsing course. Recently, the clinical outcome of FL has been distinguished by immune microenvironment-associated gene signatures. In our study, gene expression profiling (GEP) was performed in 31 non-selected patients with follicular lymphoma (FL), 12 of whom were in relapse and the remaining 19 newly diagnosed. A custom oligonucleotide microarray was used which contained probes for about 3500 genes, including those that had been previously published as demonstrating significant prognostic value. An unsupervised approach was not able to recognize clinically different FLs. As the previously published prognostically relevant gene signatures could not be properly verified, probably due to microarray platform differences, template matching was therefore used in order to define two gene sets with differential gene expression among our samples.
dcterms:title
Gene expression profiling in follicular lymphoma and its implication for clinical practice Gene expression profiling in follicular lymphoma and its implication for clinical practice
skos:prefLabel
Gene expression profiling in follicular lymphoma and its implication for clinical practice Gene expression profiling in follicular lymphoma and its implication for clinical practice
skos:notation
RIV/65269705:_____/11:#0001275!RIV12-MZ0-65269705
n7:predkladatel
n19:ico%3A65269705
n3:aktivita
n11:P n11:Z
n3:aktivity
P(FR-TI2/254), P(NS10439), Z(MSM0021622430)
n3:cisloPeriodika
1
n3:dodaniDat
n15:2012
n3:domaciTvurceVysledku
n5:9485066 n5:2927551 n5:7801386 n5:1957864 n5:7248857 n5:7997825 n5:4771060 n5:4376285 n5:6792081
n3:druhVysledku
n4:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
200880
n3:idVysledku
RIV/65269705:_____/11:#0001275
n3:jazykVysledku
n14:eng
n3:klicovaSlova
follicular lymphoma
n3:klicoveSlovo
n13:follicular%20lymphoma
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[DB2B09287880]
n3:nazevZdroje
Leukemia & Lymphoma
n3:obor
n12:FD
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
9
n3:projekt
n10:FR-TI2%2F254 n10:NS10439
n3:rokUplatneniVysledku
n15:2011
n3:svazekPeriodika
52
n3:tvurceVysledku
Vášová, Ingrid Šupíková, Jana Křen, Leoš Tichý, Boris Šálek, David Janíková, Andrea Mayer, Jiří Pospíšilová, Šárka Stano Kozubík, Kateřina
n3:wos
000286901600012
n3:zamer
n17:MSM0021622430
s:issn
1042-8194
s:numberOfPages
10
n20:doi
10.3109/10428194.2010.531412