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Statements

Subject Item
n2:RIV%2F65269705%3A_____%2F10%3A%230001196%21RIV11-MZ0-65269705
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Following a trauma, the capacity of the growth plate to regenerate tends to decrease. Evaluating the capacity of mesenchymal stem cells (MSCs) to heal defects in the injured physis is one of the current issues of contemporary research. Our study draws on a successful experiment with similar objectives which was previously carried out on the model of a New Zealand white rabbit. Long-term research included a group of 10 miniature pigs: allogeneic mesenchymal stem cells were transplanted into an iatrogenically-induced defect in the lateral section of the distal physis of the left femur. The right femur with the same defect in the distal physis, but without transplanted stem cells, served as a control. To transfer MSCs, a recently developed porous scaffold was used, based on collagen and chitosan, constituting a compact tube into which MSCs were implanted. The pigs were euthanized 4 months after the transplantation. Following a trauma, the capacity of the growth plate to regenerate tends to decrease. Evaluating the capacity of mesenchymal stem cells (MSCs) to heal defects in the injured physis is one of the current issues of contemporary research. Our study draws on a successful experiment with similar objectives which was previously carried out on the model of a New Zealand white rabbit. Long-term research included a group of 10 miniature pigs: allogeneic mesenchymal stem cells were transplanted into an iatrogenically-induced defect in the lateral section of the distal physis of the left femur. The right femur with the same defect in the distal physis, but without transplanted stem cells, served as a control. To transfer MSCs, a recently developed porous scaffold was used, based on collagen and chitosan, constituting a compact tube into which MSCs were implanted. The pigs were euthanized 4 months after the transplantation.
dcterms:title
Transplantation of Allogeneic Mesenchymal Stem Cells into Physeal Defects in the Prevention of Bone Bridge Formation in Pigs Transplantation of Allogeneic Mesenchymal Stem Cells into Physeal Defects in the Prevention of Bone Bridge Formation in Pigs
skos:prefLabel
Transplantation of Allogeneic Mesenchymal Stem Cells into Physeal Defects in the Prevention of Bone Bridge Formation in Pigs Transplantation of Allogeneic Mesenchymal Stem Cells into Physeal Defects in the Prevention of Bone Bridge Formation in Pigs
skos:notation
RIV/65269705:_____/10:#0001196!RIV11-MZ0-65269705
n4:aktivita
n12:P
n4:aktivity
P(NS9896)
n4:dodaniDat
n9:2011
n4:domaciTvurceVysledku
n14:3547582 n14:7248857 n14:3488349 n14:5523532
n4:druhVysledku
n10:O
n4:duvernostUdaju
n6:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
293387
n4:idVysledku
RIV/65269705:_____/10:#0001196
n4:jazykVysledku
n16:eng
n4:klicovaSlova
mesenchymal stem cells
n4:klicoveSlovo
n5:mesenchymal%20stem%20cells
n4:kontrolniKodProRIV
[C09A77C9066D]
n4:obor
n13:FI
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
7
n4:projekt
n11:NS9896
n4:rokUplatneniVysledku
n9:2010
n4:tvurceVysledku
Plánka, Ladislav Křen, Leoš Starý, D. Gál, Petr