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Statements

Subject Item
n2:RIV%2F65269705%3A_____%2F10%3A%230001054%21RIV11-MZ0-65269705
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Schizophrenia is ranked among multifactor diseases in whose pathogenesis, besides environmental factors, an interplay of functional polymorphisms of a larger number of candidate genes is involved. Neurodevelopmental abnormities are among the most accepted hypotheses in the etiology of schizophrenia. Recently, the role of oligodendrocytes in the development of the cortex has been cited repeatedly. During their various phases of differentiation oligodendrocytes present on their surfaces diverse receptors, among others the mu-opioid receptor (OPRM1). The study was focused on the relationship between the functional A118G polymorphism of the OPRM1 gene (rs1799971) and schizophrenia in groups of 130 male patients and 452 male controls. An association study revealed yet unpublished statistically significant difference of allelic and genotypic frequencies between the control and patient groups. Schizophrenia is ranked among multifactor diseases in whose pathogenesis, besides environmental factors, an interplay of functional polymorphisms of a larger number of candidate genes is involved. Neurodevelopmental abnormities are among the most accepted hypotheses in the etiology of schizophrenia. Recently, the role of oligodendrocytes in the development of the cortex has been cited repeatedly. During their various phases of differentiation oligodendrocytes present on their surfaces diverse receptors, among others the mu-opioid receptor (OPRM1). The study was focused on the relationship between the functional A118G polymorphism of the OPRM1 gene (rs1799971) and schizophrenia in groups of 130 male patients and 452 male controls. An association study revealed yet unpublished statistically significant difference of allelic and genotypic frequencies between the control and patient groups.
dcterms:title
A118G polymorphism of OPRM1 gene is associated with schizophrenia A118G polymorphism of OPRM1 gene is associated with schizophrenia
skos:prefLabel
A118G polymorphism of OPRM1 gene is associated with schizophrenia A118G polymorphism of OPRM1 gene is associated with schizophrenia
skos:notation
RIV/65269705:_____/10:#0001054!RIV11-MZ0-65269705
n3:aktivita
n5:S n5:P n5:Z
n3:aktivity
P(NR9298), S, Z(MSM0021622413)
n3:cisloPeriodika
1
n3:dodaniDat
n4:2011
n3:domaciTvurceVysledku
n14:4520831
n3:druhVysledku
n17:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
248326
n3:idVysledku
RIV/65269705:_____/10:#0001054
n3:jazykVysledku
n18:eng
n3:klicovaSlova
schizophrenia
n3:klicoveSlovo
n9:schizophrenia
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[1B339AD1DFF9]
n3:nazevZdroje
Journal of Molecular Neuroscience
n3:obor
n15:FL
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:projekt
n11:NR9298
n3:rokUplatneniVysledku
n4:2010
n3:svazekPeriodika
41
n3:tvurceVysledku
Šerý, Omar Přikryl, Radovan
n3:wos
000275905400028
n3:zamer
n16:MSM0021622413
s:issn
0895-8696
s:numberOfPages
4