This HTML5 document contains 46 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n10http://linked.opendata.cz/resource/domain/vavai/projekt/
n13http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F65269705%3A_____%2F10%3A%230001023%21RIV11-MZ0-65269705/
n6http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n14http://linked.opendata.cz/ontology/domain/vavai/
n15http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
n5http://linked.opendata.cz/ontology/domain/vavai/riv/
skoshttp://www.w3.org/2004/02/skos/core#
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n16http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n12http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n17http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n8http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n18http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n7http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n11http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F65269705%3A_____%2F10%3A%230001023%21RIV11-MZ0-65269705
rdf:type
n14:Vysledek skos:Concept
dcterms:description
We investigated the possible modulation by LOX/ COX inhibitors of all-trans retinoic acid (ATRA)-induced cell differentiation in two established neuroblastoma cell lines, SH-SY5Y and SK-N-BE(2). Caffeic acid, as an inhibitor of 5-lipoxygenase, and celecoxib, as an inhibitor of cyclooxygenase-2, were chosen for this study. The effects of the combined treatment with ATRA and LOX/COX inhibitors on neuroblastoma cells were studied using cell morphology assessment, detection of differentiation markers by immunoblotting, measurement of proliferation activity, and cell cycle analysis and apoptosis detection by flow cytometry. The results clearly demonstrated the potential of caffeic acid to enhance ATRA-induced cell differentiation, especially in the SK-N-BE(2) cell line, whereas application of celecoxib alone or with ATRA led predominantly to cytotoxic effects in both cell lines. We investigated the possible modulation by LOX/ COX inhibitors of all-trans retinoic acid (ATRA)-induced cell differentiation in two established neuroblastoma cell lines, SH-SY5Y and SK-N-BE(2). Caffeic acid, as an inhibitor of 5-lipoxygenase, and celecoxib, as an inhibitor of cyclooxygenase-2, were chosen for this study. The effects of the combined treatment with ATRA and LOX/COX inhibitors on neuroblastoma cells were studied using cell morphology assessment, detection of differentiation markers by immunoblotting, measurement of proliferation activity, and cell cycle analysis and apoptosis detection by flow cytometry. The results clearly demonstrated the potential of caffeic acid to enhance ATRA-induced cell differentiation, especially in the SK-N-BE(2) cell line, whereas application of celecoxib alone or with ATRA led predominantly to cytotoxic effects in both cell lines.
dcterms:title
Influence of LOX/COX inhibitors on cell differentation induced by all-trans retinoic acid in neuroblastoma cell lines. Influence of LOX/COX inhibitors on cell differentation induced by all-trans retinoic acid in neuroblastoma cell lines.
skos:prefLabel
Influence of LOX/COX inhibitors on cell differentation induced by all-trans retinoic acid in neuroblastoma cell lines. Influence of LOX/COX inhibitors on cell differentation induced by all-trans retinoic acid in neuroblastoma cell lines.
skos:notation
RIV/65269705:_____/10:#0001023!RIV11-MZ0-65269705
n5:aktivita
n8:P n8:Z
n5:aktivity
P(GD204/08/H054), P(NR9341), Z(MSM0021622415)
n5:cisloPeriodika
2
n5:dodaniDat
n11:2011
n5:domaciTvurceVysledku
n6:5260612 n6:1398954 n6:5658179 n6:1195271 n6:2299690
n5:druhVysledku
n7:J
n5:duvernostUdaju
n12:S
n5:entitaPredkladatele
n13:predkladatel
n5:idSjednocenehoVysledku
263696
n5:idVysledku
RIV/65269705:_____/10:#0001023
n5:jazykVysledku
n17:eng
n5:klicovaSlova
neuroblastoma
n5:klicoveSlovo
n16:neuroblastoma
n5:kodStatuVydavatele
GR - Řecká republika
n5:kontrolniKodProRIV
[4285ACEBFDE0]
n5:nazevZdroje
International Journal of Molecular Medicine
n5:obor
n18:FD
n5:pocetDomacichTvurcuVysledku
5
n5:pocetTvurcuVysledku
7
n5:projekt
n10:GD204%2F08%2FH054 n10:NR9341
n5:rokUplatneniVysledku
n11:2010
n5:svazekPeriodika
25
n5:tvurceVysledku
Zitterbart, Karel Hermanová, Markéta Veselská, Renata Loja, Tomáš Štěrba, Jaroslav
n5:wos
000273862300013
n5:zamer
n15:MSM0021622415
s:issn
1107-3756
s:numberOfPages
9