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Statements

Subject Item
n2:RIV%2F65269705%3A_____%2F10%3A%230000938%21RIV11-MZ0-65269705
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Patients with fulminant progression of multiple myeloma after autologous stem cell transplantation (ASCT) have poor prognosis. Pancytopenia, extramedullary disease, and/or renal impairment are often present, and treatment options are limited. We have retrospectively evaluated 31 pts with FPG of MM after ASCT who were treated upfront salvage therapy with melphalan followed by PBSC support and consolidation therapy using regimens containing thalidomide or bortezomib.Treatment with upfront MEL 100 followed by a thalidomide or bortezomibbased regimen can prolong overall survival to more than 12 months in 33% of pts with fulminant progression of MM. Patients with fulminant progression of multiple myeloma after autologous stem cell transplantation (ASCT) have poor prognosis. Pancytopenia, extramedullary disease, and/or renal impairment are often present, and treatment options are limited. We have retrospectively evaluated 31 pts with FPG of MM after ASCT who were treated upfront salvage therapy with melphalan followed by PBSC support and consolidation therapy using regimens containing thalidomide or bortezomib.Treatment with upfront MEL 100 followed by a thalidomide or bortezomibbased regimen can prolong overall survival to more than 12 months in 33% of pts with fulminant progression of MM.
dcterms:title
Salvage treatment with upfront melphalan 100 mg/m(2) and consolidation with novel drugs for fulminant progression of multiple myeloma Salvage treatment with upfront melphalan 100 mg/m(2) and consolidation with novel drugs for fulminant progression of multiple myeloma
skos:prefLabel
Salvage treatment with upfront melphalan 100 mg/m(2) and consolidation with novel drugs for fulminant progression of multiple myeloma Salvage treatment with upfront melphalan 100 mg/m(2) and consolidation with novel drugs for fulminant progression of multiple myeloma
skos:notation
RIV/65269705:_____/10:#0000938!RIV11-MZ0-65269705
n3:aktivita
n14:P n14:V
n3:aktivity
P(NR9225), P(NR9317), V
n3:cisloPeriodika
5
n3:dodaniDat
n6:2011
n3:domaciTvurceVysledku
n4:9685596 n4:5551579 n4:1285815 n4:4376285 n4:7227086 n4:9622748 n4:1765272 n4:1447963 n4:9890009
n3:druhVysledku
n13:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
286302
n3:idVysledku
RIV/65269705:_____/10:#0000938
n3:jazykVysledku
n10:eng
n3:klicovaSlova
multiple myeloma
n3:klicoveSlovo
n5:multiple%20myeloma
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[A9E7C98D31DC]
n3:nazevZdroje
Annals of Hematology
n3:obor
n12:FD
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
11
n3:projekt
n9:NR9225 n9:NR9317
n3:rokUplatneniVysledku
n6:2010
n3:svazekPeriodika
89
n3:tvurceVysledku
Hájek, Roman Zahradová, Lenka Mayer, Jiří Pour, Luděk Vorlíček, Jiří Křivanová, Andrea Krejčí, Marta Adam, Zdeněk Sandecká, Viera
n3:wos
000275709100007
s:issn
0939-5555
s:numberOfPages
5