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Statements

Subject Item
n2:RIV%2F65269705%3A_____%2F10%3A%230000937%21RIV11-MZ0-65269705
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Chronic lymhocytic leukemia (CLL) is characterized by a monoclonal expansion of mature B-lymphocytes. Mutational status of the immunoglobulin variable heavy chain region (IGVH) gene stratifies CLL patients into two prognostic groups. We performed microarray analysis of CLL cells using the Agilent platform to detect the most important gene expression differences regarding IGVH status in CLL cells. We analyzed a cohort of 118 CLL patients with different IGVH mutational status and completely characterized all described prognostic markers using expression microarrays and quantitative real-time RT-PCR (reverse transcription PCR). We detected lymphocyte-activation gene 3 (LAG3) as a novel prognostic marker: LAG3 high expression in CLL cells correlates with unmutated IGVH (P<0.0001) and reduced treatment free survival (P=0.0087). Furthermore, quantitative real-time RT-PCR analysis identified a gene-set (LAG3, LPL, ZAP70) whose overexpression is assigned to unmutated IGVH with 90% specificity (P<0.0001). Chronic lymhocytic leukemia (CLL) is characterized by a monoclonal expansion of mature B-lymphocytes. Mutational status of the immunoglobulin variable heavy chain region (IGVH) gene stratifies CLL patients into two prognostic groups. We performed microarray analysis of CLL cells using the Agilent platform to detect the most important gene expression differences regarding IGVH status in CLL cells. We analyzed a cohort of 118 CLL patients with different IGVH mutational status and completely characterized all described prognostic markers using expression microarrays and quantitative real-time RT-PCR (reverse transcription PCR). We detected lymphocyte-activation gene 3 (LAG3) as a novel prognostic marker: LAG3 high expression in CLL cells correlates with unmutated IGVH (P<0.0001) and reduced treatment free survival (P=0.0087). Furthermore, quantitative real-time RT-PCR analysis identified a gene-set (LAG3, LPL, ZAP70) whose overexpression is assigned to unmutated IGVH with 90% specificity (P<0.0001).
dcterms:title
High Expression of Lymphocyte-Activation Gene 3 in Chronic Lymphocytic Leukemia Cells is Associated with Unmutated IGHV and Reduced Treatment-Free Survival High Expression of Lymphocyte-Activation Gene 3 in Chronic Lymphocytic Leukemia Cells is Associated with Unmutated IGHV and Reduced Treatment-Free Survival
skos:prefLabel
High Expression of Lymphocyte-Activation Gene 3 in Chronic Lymphocytic Leukemia Cells is Associated with Unmutated IGHV and Reduced Treatment-Free Survival High Expression of Lymphocyte-Activation Gene 3 in Chronic Lymphocytic Leukemia Cells is Associated with Unmutated IGHV and Reduced Treatment-Free Survival
skos:notation
RIV/65269705:_____/10:#0000937!RIV11-MZ0-65269705
n3:aktivita
n7:Z n7:P
n3:aktivity
P(NR8448), P(NR9293), P(NS10439), Z(MSM0021622430)
n3:cisloPeriodika
3
n3:dodaniDat
n10:2011
n3:domaciTvurceVysledku
n8:1248790 n8:4376285 n8:7997825 n8:5802245 n8:1957864 n8:2093995 n8:4629604 n8:3169561 n8:5761727 n8:9811524
n3:druhVysledku
n12:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
261500
n3:idVysledku
RIV/65269705:_____/10:#0000937
n3:jazykVysledku
n16:eng
n3:klicovaSlova
Leukemia
n3:klicoveSlovo
n18:Leukemia
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[14557243A02A]
n3:nazevZdroje
Journal of Molecular Diagnostics
n3:obor
n5:FD
n3:pocetDomacichTvurcuVysledku
10
n3:pocetTvurcuVysledku
10
n3:projekt
n4:NR8448 n4:NS10439 n4:NR9293
n3:rokUplatneniVysledku
n10:2010
n3:svazekPeriodika
12
n3:tvurceVysledku
Trbušek, Martin Kotašková, Jana Doubek, Michael Malčíková, Jitka Pospíšilová, Šárka Skuhrová Francová, Hana Brychtová, Yvonna Mayer, Jiří Tichý, Boris Kabathová, Jitka
n3:wos
000277531700010
n3:zamer
n13:MSM0021622430
s:issn
1525-1578
s:numberOfPages
7