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Statements

Subject Item
n2:RIV%2F65269705%3A_____%2F09%3A%230000799%21RIV10-MZ0-65269705
rdf:type
n17:Vysledek skos:Concept
dcterms:description
Transcranial magnetic stimulation is a neurophysiological method which enables direct quantitative in vivo assessment of cortical excitability and inhibition. The aim of the study was to assess the impact of paliperidone on the motor threshold and cortical silent period, in a drug-naive patient, with first episode schizophrenia using this technique. Paliperidone monotherapy caused a significant reduction of severity of schizophrenic symptomatology in the patient. At the same time, a significant prolongation of the cortical silent period, from 118.68 ms before to 185.13 ms after therapy, occurred. Because the cortical silent period is a function of GABAB receptors, we can assume that paliperidone may have the ability to enhance GABAB receptor-mediated neurotransmission. Transcranial magnetic stimulation is a neurophysiological method which enables direct quantitative in vivo assessment of cortical excitability and inhibition. The aim of the study was to assess the impact of paliperidone on the motor threshold and cortical silent period, in a drug-naive patient, with first episode schizophrenia using this technique. Paliperidone monotherapy caused a significant reduction of severity of schizophrenic symptomatology in the patient. At the same time, a significant prolongation of the cortical silent period, from 118.68 ms before to 185.13 ms after therapy, occurred. Because the cortical silent period is a function of GABAB receptors, we can assume that paliperidone may have the ability to enhance GABAB receptor-mediated neurotransmission.
dcterms:title
Paliperidon mediated modification of cortical inhibition Paliperidon mediated modification of cortical inhibition
skos:prefLabel
Paliperidon mediated modification of cortical inhibition Paliperidon mediated modification of cortical inhibition
skos:notation
RIV/65269705:_____/09:#0000799!RIV10-MZ0-65269705
n3:aktivita
n8:Z n8:P
n3:aktivity
P(NS9890), Z(MSM0021622404)
n3:cisloPeriodika
30
n3:dodaniDat
n6:2010
n3:domaciTvurceVysledku
n9:3871029 n9:4520831 n9:5303125 n9:6925472
n3:druhVysledku
n15:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
332557
n3:idVysledku
RIV/65269705:_____/09:#0000799
n3:jazykVysledku
n5:eng
n3:klicovaSlova
cortical silent period; first episode; paliperidon; schizophrenia
n3:klicoveSlovo
n4:paliperidon n4:cortical%20silent%20period n4:first%20episode n4:schizophrenia
n3:kodStatuVydavatele
SE - Švédské království
n3:kontrolniKodProRIV
[A265145363C9]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n10:FL
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n18:NS9890
n3:rokUplatneniVysledku
n6:2009
n3:svazekPeriodika
2009
n3:tvurceVysledku
Ustohal, Libor Přikrylová-Kučerová, Hana Češková, Eva Přikryl, Radovan
n3:wos
000272199300018
n3:zamer
n14:MSM0021622404
s:issn
0172-780X
s:numberOfPages
4