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Statements

Subject Item
n2:RIV%2F65269705%3A_____%2F03%3A00007983%21RIV%2F2004%2FMZ0%2FL43004%2FN
rdf:type
n12:Vysledek skos:Concept
dcterms:description
Both CD 8+ and CD 4+ T cells with specific activity against tumor antigens are needed for an efficient antitumor immune response. Activation snd proliferation of T cells require cellular interactions including adhesion,recognition of peptides presented by MHC molecules to the T cells receptor, and costimulation. In a series of experiments we attempted to generate and expand specific T cells by repeated stimulation using antigen-loaded autologous dendritic cells (DCs). Dcs werwobtained from peripheral blood mononuclear cells (PBMC) in the presence of IL ? 4 and GM-CSF. TNF ?á was added to induce maturation. A conjugate of myeloma idiotypic protein wih keyhole limpet hemocyanin was used as antigen. Nonadherent peripheral blood mononuclear cells were cultured in the presence of IL-2 and IL-7. Autologous DCs were added to the lymphocyte on days 3,10, and17. The lymphocytes were stimulated by high concentration of IL-2 between days 21 and 27. Lymphocytes harvested on day 27 proliferated in response to anit Both CD 8+ and CD 4+ T cells with specific activity against tumor antigens are needed for an efficient antitumor immune response. Activation snd proliferation of T cells require cellular interactions including adhesion,recognition of peptides presented by MHC molecules to the T cells receptor, and costimulation. In a series of experiments we attempted to generate and expand specific T cells by repeated stimulation using antigen-loaded autologous dendritic cells (DCs). Dcs werwobtained from peripheral blood mononuclear cells (PBMC) in the presence of IL ? 4 and GM-CSF. TNF ?á was added to induce maturation. A conjugate of myeloma idiotypic protein wih keyhole limpet hemocyanin was used as antigen. Nonadherent peripheral blood mononuclear cells were cultured in the presence of IL-2 and IL-7. Autologous DCs were added to the lymphocyte on days 3,10, and17. The lymphocytes were stimulated by high concentration of IL-2 between days 21 and 27. Lymphocytes harvested on day 27 proliferated in response to anit
dcterms:title
Low antigen-dependent activity of T cells after repeated stimulation using dendritic cells and expansion with interleukin-2 Low antigen-dependent activity of T cells after repeated stimulation using dendritic cells and expansion with interleukin-2
skos:prefLabel
Low antigen-dependent activity of T cells after repeated stimulation using dendritic cells and expansion with interleukin-2 Low antigen-dependent activity of T cells after repeated stimulation using dendritic cells and expansion with interleukin-2
skos:notation
RIV/65269705:_____/03:00007983!RIV/2004/MZ0/L43004/N
n3:strany
120-123
n3:aktivita
n9:P
n3:aktivity
P(NC6763)
n3:cisloPeriodika
5
n3:dodaniDat
n4:2004
n3:domaciTvurceVysledku
n11:1447033
n3:druhVysledku
n10:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
613910
n3:idVysledku
RIV/65269705:_____/03:00007983
n3:jazykVysledku
n16:eng
n3:klicovaSlova
T cells;dendritic cells;immunotherapy;in vitor cell culture
n3:klicoveSlovo
n5:T%20cells n5:immunotherapy n5:dendritic%20cells n5:in%20vitor%20cell%20culture
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[6E5FB342AAD5]
n3:nazevZdroje
Neoplasma
n3:obor
n6:FD
n3:pocetDomacichTvurcuVysledku
9
n3:pocetTvurcuVysledku
9
n3:pocetUcastnikuAkce
0
n3:pocetZahranicnichUcastnikuAkce
0
n3:projekt
n15:NC6763
n3:rokUplatneniVysledku
n4:2003
n3:svazekPeriodika
50
n3:tvurceVysledku
Büchler, Tomáš
s:issn
0028-2685
s:numberOfPages
4