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Statements

Subject Item
n2:RIV%2F62690094%3A18470%2F14%3A50002388%21RIV15-MSM-18470___
rdf:type
skos:Concept n10:Vysledek
dcterms:description
Aflatoxins are potent hepatocarcinogen in animal models and suspected carcinogen in humans. The most important aflatoxin in terms of toxic potency and occurrence is aflatoxin B1 (AFB1). In this review, we mainly summarized the key metabolizing enzymes of AFB1 in animals and humans. Moreover, the interindividual and the interspecies differences in AFB1 metabolism are highly concerned. In human liver, CYP3A4 plays an important role in biotransforming AFB1 to the toxic product AFB1-8,9-epoxide. In human lung, CYP2A13 has a significant activity in metabolizing AFB1 to AFB1-8,9-epoxide and AFM1-8,9-epoxide. The epoxide of AFB1-8,9-epoxide could conjugate with glutathione to reduce the toxicity by glutathione-S-transferase (GST). In poultry species, CYP2A6, CYP3A37, CYP1A5, and CYP1A1 are responsible for bioactivation of AFB1. There are interindividual variations in the rate of activation of aflatoxins in various species, and there are also differences between children and adults. The age and living regions are important factors affecting resistance of species to AFB1. The rate of AFB1-8,9-epoxide formation and its conjugation with glutathione are key parameters in interspecies and interindividual differences in sensitivity to the toxic effect of AFB1. This review provides an important information for key metabolizing enzymes and the global metabolism of aflatoxins in different species. Aflatoxins are potent hepatocarcinogen in animal models and suspected carcinogen in humans. The most important aflatoxin in terms of toxic potency and occurrence is aflatoxin B1 (AFB1). In this review, we mainly summarized the key metabolizing enzymes of AFB1 in animals and humans. Moreover, the interindividual and the interspecies differences in AFB1 metabolism are highly concerned. In human liver, CYP3A4 plays an important role in biotransforming AFB1 to the toxic product AFB1-8,9-epoxide. In human lung, CYP2A13 has a significant activity in metabolizing AFB1 to AFB1-8,9-epoxide and AFM1-8,9-epoxide. The epoxide of AFB1-8,9-epoxide could conjugate with glutathione to reduce the toxicity by glutathione-S-transferase (GST). In poultry species, CYP2A6, CYP3A37, CYP1A5, and CYP1A1 are responsible for bioactivation of AFB1. There are interindividual variations in the rate of activation of aflatoxins in various species, and there are also differences between children and adults. The age and living regions are important factors affecting resistance of species to AFB1. The rate of AFB1-8,9-epoxide formation and its conjugation with glutathione are key parameters in interspecies and interindividual differences in sensitivity to the toxic effect of AFB1. This review provides an important information for key metabolizing enzymes and the global metabolism of aflatoxins in different species.
dcterms:title
Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences
skos:prefLabel
Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences
skos:notation
RIV/62690094:18470/14:50002388!RIV15-MSM-18470___
n3:aktivita
n17:I
n3:aktivity
I
n3:cisloPeriodika
9
n3:dodaniDat
n7:2015
n3:domaciTvurceVysledku
n12:3289133
n3:druhVysledku
n15:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
28536
n3:idVysledku
RIV/62690094:18470/14:50002388
n3:jazykVysledku
n5:eng
n3:klicovaSlova
Interspecies differences; Interindividual; Metabolism; Metabolizing enzymes; AFB1; Aflatoxins
n3:klicoveSlovo
n4:Interspecies%20differences n4:AFB1 n4:Metabolism n4:Aflatoxins n4:Metabolizing%20enzymes n4:Interindividual
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[1911F7C7EFC1]
n3:nazevZdroje
Archives of toxicology
n3:obor
n18:FR
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
3
n3:rokUplatneniVysledku
n7:2014
n3:svazekPeriodika
88
n3:tvurceVysledku
Kuča, Kamil Wu, Qinghua Dohnal, Vlastimil
n3:wos
000340585900002
s:issn
0340-5761
s:numberOfPages
10
n16:doi
10.1007/s00204-014-1312-9
n9:organizacniJednotka
18470