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Statements

Subject Item
n2:RIV%2F62690094%3A18470%2F12%3A50000664%21RIV13-MSM-18470___
rdf:type
n6:Vysledek skos:Concept
rdfs:seeAlso
http://informahealthcare.com/doi/abs/10.1517/17460441.2012.729037
dcterms:description
Determination of acetylcholinesterase and butyrylcholinesterase activity has become an important tool in drug design and discovery as well as in medicine and toxicology. There are a large number of compounds that are able to modulate cholinesterase activity. These compounds can be used for pharmacological management of various disorders (e.g., Alzheimer's disease, myasthenia Gravis). Moreover, organophosphate poisoning is frequently diagnosed via a cholinesterase activity assay. This broad variety of methods has been developed over the past decades for cholinesterase activity quantification. Determination of acetylcholinesterase and butyrylcholinesterase activity has become an important tool in drug design and discovery as well as in medicine and toxicology. There are a large number of compounds that are able to modulate cholinesterase activity. These compounds can be used for pharmacological management of various disorders (e.g., Alzheimer's disease, myasthenia Gravis). Moreover, organophosphate poisoning is frequently diagnosed via a cholinesterase activity assay. This broad variety of methods has been developed over the past decades for cholinesterase activity quantification.
dcterms:title
The progress in the cholinesterase quantification methods The progress in the cholinesterase quantification methods
skos:prefLabel
The progress in the cholinesterase quantification methods The progress in the cholinesterase quantification methods
skos:notation
RIV/62690094:18470/12:50000664!RIV13-MSM-18470___
n6:predkladatel
n19:orjk%3A18470
n3:aktivita
n15:I n15:S n15:P
n3:aktivity
I, P(NT12062), S
n3:cisloPeriodika
12
n3:dodaniDat
n14:2013
n3:domaciTvurceVysledku
n13:6469922
n3:druhVysledku
n18:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n21:predkladatel
n3:idSjednocenehoVysledku
162675
n3:idVysledku
RIV/62690094:18470/12:50000664
n3:jazykVysledku
n20:eng
n3:klicovaSlova
titrimetry; radiometry; potentiometry; photometry; manometry; in vitro; fluorometry; butyrylcholinesterase; biosensors; acetylcholinesterase
n3:klicoveSlovo
n4:butyrylcholinesterase n4:in%20vitro n4:titrimetry n4:acetylcholinesterase n4:fluorometry n4:manometry n4:photometry n4:biosensors n4:radiometry n4:potentiometry
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[D7FA7529395F]
n3:nazevZdroje
Expert opinion on drug discovery
n3:obor
n12:FR
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:projekt
n16:NT12062
n3:rokUplatneniVysledku
n14:2012
n3:svazekPeriodika
7
n3:tvurceVysledku
Holas, Ondřej Kuča, Kamil Pohanka, Miroslav Musílek, Kamil
n3:wos
000312700700007
s:issn
1746-0441
s:numberOfPages
17
n17:doi
10.1517/17460441.2012.729037
n8:organizacniJednotka
18470