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Statements

Subject Item
n2:RIV%2F62157124%3A16810%2F14%3A43872687%21RIV15-MSM-16810___
rdf:type
n9:Vysledek skos:Concept
dcterms:description
For centuries, domestic horses have represented an important means of transport and served as working and companion animals. Although their role in transportation is less important today, many horse breeds are still subject to intense selection based on their pattern of locomotion. A striking example of such a selected trait is the ability of a horse to perform additional gaits other than the common walk, trot and gallop. Those could be four-beat ambling gaits, which are particularly smooth and comfortable for the rider, or pace, used mainly in racing. Gaited horse breeds occur around the globe, suggesting that gaitedness is an old trait, selected for in many breeds. A recent study discovered that a nonsense mutation in DMRT3 has a major impact on gaitedness in horses and is present at a high frequency in gaited breeds and in horses bred for harness racing. Here, we report a study of the worldwide distribution of this mutation. We genotyped 4396 horses representing 141 horse breeds for the DMRT3 stop mutation. More than half (2749) of these horses also were genotyped for a SNP situated 32kb upstream of the DMRT3 nonsense mutation because these two SNPs are in very strong linkage disequilibrium. We show that the DMRT3 mutation is present in 68 of the 141 genotyped horse breeds at a frequency ranging from 1% to 100%. We also show that the mutation is not limited to a geographical area, but is found worldwide. The breeds with a high frequency of the stop mutation (}50%) are either classified as gaited or bred for harness racing. For centuries, domestic horses have represented an important means of transport and served as working and companion animals. Although their role in transportation is less important today, many horse breeds are still subject to intense selection based on their pattern of locomotion. A striking example of such a selected trait is the ability of a horse to perform additional gaits other than the common walk, trot and gallop. Those could be four-beat ambling gaits, which are particularly smooth and comfortable for the rider, or pace, used mainly in racing. Gaited horse breeds occur around the globe, suggesting that gaitedness is an old trait, selected for in many breeds. A recent study discovered that a nonsense mutation in DMRT3 has a major impact on gaitedness in horses and is present at a high frequency in gaited breeds and in horses bred for harness racing. Here, we report a study of the worldwide distribution of this mutation. We genotyped 4396 horses representing 141 horse breeds for the DMRT3 stop mutation. More than half (2749) of these horses also were genotyped for a SNP situated 32kb upstream of the DMRT3 nonsense mutation because these two SNPs are in very strong linkage disequilibrium. We show that the DMRT3 mutation is present in 68 of the 141 genotyped horse breeds at a frequency ranging from 1% to 100%. We also show that the mutation is not limited to a geographical area, but is found worldwide. The breeds with a high frequency of the stop mutation (}50%) are either classified as gaited or bred for harness racing.
dcterms:title
Worldwide frequency distribution of the 'Gait keeper' mutation in the DMRT3 gene Worldwide frequency distribution of the 'Gait keeper' mutation in the DMRT3 gene
skos:prefLabel
Worldwide frequency distribution of the 'Gait keeper' mutation in the DMRT3 gene Worldwide frequency distribution of the 'Gait keeper' mutation in the DMRT3 gene
skos:notation
RIV/62157124:16810/14:43872687!RIV15-MSM-16810___
n3:aktivita
n12:P n12:I
n3:aktivity
I, P(ED1.1.00/02.0068)
n3:cisloPeriodika
2
n3:dodaniDat
n17:2015
n3:domaciTvurceVysledku
n6:7286384 n6:3009386
n3:druhVysledku
n13:J
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
56382
n3:idVysledku
RIV/62157124:16810/14:43872687
n3:jazykVysledku
n5:eng
n3:klicovaSlova
running walk; pace; locomotion; horse; domestication; Ambling
n3:klicoveSlovo
n7:locomotion n7:horse n7:domestication n7:running%20walk n7:pace n7:Ambling
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[7B0F0503CDA7]
n3:nazevZdroje
Animal Genetics
n3:obor
n16:GJ
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
21
n3:projekt
n18:ED1.1.00%2F02.0068
n3:rokUplatneniVysledku
n17:2014
n3:svazekPeriodika
45
n3:tvurceVysledku
Cothran, E. G. Lindgren, G. Imsland, F. Tozaki, T. Roed, K. H. Andersson, L. S. Mikko, S. Hořín, Petr Reissmann, M. Imsland, P. Vega-Pla, J. L. Dunner, S. Penedo, M.C.T. Promerova, M. Yousefi-Mashouf, N. Mehrabani-Yeganeh, H. Schwochow, D. Juras, R. Bellone, R. Andersson, L. Modrý, David
n3:wos
000332140000014
s:issn
0268-9146
s:numberOfPages
9
n15:doi
10.1111/age.12120
n19:organizacniJednotka
16810