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Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F14%3A43873278%21RIV15-MSM-16370___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
In order to find out if new perspective antagonists of beta-adrenergic receptors, ortho-/meta-alkoxyphenylcarbamic acid esters containing fluorinated N-phenylpiperazine fragment (labelled as 6a-6f and 8a-8e), might also act as the antioxidants, the aim of current study was to investigate their antioxidant profile by applying two in vitro methods. Following mentioned, the capability of these compounds to reduce relatively stable reference 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radicals in performed spectrophotometric analyses and to protect tyrosine from the peroxynitrite mediated nitration by applying the HPLC method was inspected. The position of alkoxy side chain bonded to lipophilic aromatic moiety as well as the ability of hydrogen bond formation and electrostatic effects, which have been induced by fluoro or trifluoromethyl substitution within the aromatic fragment of 4-phenylpiperazin-1-yl, have been considered the essential factors, which have influenced an antioxidant potential of investigated molecules. It could be hypothesized that isosteric replacement of etheric bridge for carbamoyloxy moiety has not probably been favorable structural modification in terms of an anti-oxidant effect. Relatively high lipophilicity of all tested compounds might be important, however, it was not an essential aspect which has affected such potency. From the entire investigated set, ortho-methoxy substituted com-pound 6a involving 4-(4-fluorophenyl)piperazin-1-yl moiety has been able to reduce the DPPH radicals most markedly. The in vitro studies have also pointed to the most pronounced peroxynitrite ions scavenging potential of the substance 8c, a meta-propoxy substituted compound which has contained 4-(3-trifluoromethylphenyl)piperazin-1-yl group. In order to find out if new perspective antagonists of beta-adrenergic receptors, ortho-/meta-alkoxyphenylcarbamic acid esters containing fluorinated N-phenylpiperazine fragment (labelled as 6a-6f and 8a-8e), might also act as the antioxidants, the aim of current study was to investigate their antioxidant profile by applying two in vitro methods. Following mentioned, the capability of these compounds to reduce relatively stable reference 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radicals in performed spectrophotometric analyses and to protect tyrosine from the peroxynitrite mediated nitration by applying the HPLC method was inspected. The position of alkoxy side chain bonded to lipophilic aromatic moiety as well as the ability of hydrogen bond formation and electrostatic effects, which have been induced by fluoro or trifluoromethyl substitution within the aromatic fragment of 4-phenylpiperazin-1-yl, have been considered the essential factors, which have influenced an antioxidant potential of investigated molecules. It could be hypothesized that isosteric replacement of etheric bridge for carbamoyloxy moiety has not probably been favorable structural modification in terms of an anti-oxidant effect. Relatively high lipophilicity of all tested compounds might be important, however, it was not an essential aspect which has affected such potency. From the entire investigated set, ortho-methoxy substituted com-pound 6a involving 4-(4-fluorophenyl)piperazin-1-yl moiety has been able to reduce the DPPH radicals most markedly. The in vitro studies have also pointed to the most pronounced peroxynitrite ions scavenging potential of the substance 8c, a meta-propoxy substituted compound which has contained 4-(3-trifluoromethylphenyl)piperazin-1-yl group.
dcterms:title
IN VITRO ANTIOXIDANT PROPERTIES OF BASIC ortho-/meta-ALKOXYPHENYLCARBAMIC ACID ESTERS BEARING 4-(4-FLUORO-/3-TRIFLUOROMETHYLPHENYL)PIPERAZIN-1-YL FRAGMENT IN VITRO ANTIOXIDANT PROPERTIES OF BASIC ortho-/meta-ALKOXYPHENYLCARBAMIC ACID ESTERS BEARING 4-(4-FLUORO-/3-TRIFLUOROMETHYLPHENYL)PIPERAZIN-1-YL FRAGMENT
skos:prefLabel
IN VITRO ANTIOXIDANT PROPERTIES OF BASIC ortho-/meta-ALKOXYPHENYLCARBAMIC ACID ESTERS BEARING 4-(4-FLUORO-/3-TRIFLUOROMETHYLPHENYL)PIPERAZIN-1-YL FRAGMENT IN VITRO ANTIOXIDANT PROPERTIES OF BASIC ortho-/meta-ALKOXYPHENYLCARBAMIC ACID ESTERS BEARING 4-(4-FLUORO-/3-TRIFLUOROMETHYLPHENYL)PIPERAZIN-1-YL FRAGMENT
skos:notation
RIV/62157124:16370/14:43873278!RIV15-MSM-16370___
n3:aktivita
n12:S
n3:aktivity
S
n3:cisloPeriodika
23
n3:dodaniDat
n16:2015
n3:domaciTvurceVysledku
n13:1449052 n13:8728968
n3:druhVysledku
n10:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
21068
n3:idVysledku
RIV/62157124:16370/14:43873278
n3:jazykVysledku
n14:eng
n3:klicovaSlova
electronic effects; antioxidants; beta-adrenoceptor antagonists; phenylcarbamates
n3:klicoveSlovo
n4:beta-adrenoceptor%20antagonists n4:antioxidants n4:phenylcarbamates n4:electronic%20effects
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[0C4E505DD4B3]
n3:nazevZdroje
Fresenius Environmental Bulletin
n3:obor
n9:FR
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
5
n3:rokUplatneniVysledku
n16:2014
n3:svazekPeriodika
9A
n3:tvurceVysledku
Sedlárová, Eva Stanzel, Lukáš Malík, Ivan Csöllei, Jozef Muselík, Jan
n3:wos
000349805100019
s:issn
1018-4619
s:numberOfPages
8
n15:organizacniJednotka
16370