This HTML5 document contains 44 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n14http://localhost/temp/predkladatel/
n5http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n7http://linked.opendata.cz/ontology/domain/vavai/
n15http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F62157124%3A16370%2F14%3A43873200%21RIV15-MSM-16370___/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n10http://bibframe.org/vocab/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n8http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n11http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n17http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n12http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n18http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n13http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F14%3A43873200%21RIV15-MSM-16370___
rdf:type
skos:Concept n7:Vysledek
dcterms:description
The aim of this paper is the study of physico-chemical properties of the chosen compounds, derivatives of 2-hydroxy-3-[2-(4-methoxyphenyl) ethylamino]propyl-4-[(alkoxycarbonyl)amino]benzoates and 2-hydroxy-3-[2-(2-methoxyphenyl)ethylamino]propyl-4-[(alkoxycarbonyl) amino]benzoates with potential ultra-short beta-adrenolytic activity. The studied compounds are different in the position of the substituent on the benzene ring in the side chain as well as in the aromatic ring in position 4 with alkyl- (methyl-to butyl-) carbamate. The physico-chemical characteristics, for example, lipophilicity, surface activity, adsorbability, acidobasic properties etc., are very important for the explanation of the relationship between structure and biological activity of the drug. These parameters serve as the base of quantitative structure-activity study. The goal of this work is to establish the spectral characteristics of studied compounds in UV-area, pKa values, the parameters of lipophilicity (the values of Rf and RM from thin layer chromatography, retention time t'R and capacity factor k' from liquid chromatography and experimental partition coefficients log P' values), surface tension, critical micelle concentrations, the adsorbability of compounds expressed by percent of adsorbed compound on active charcoal beta% as well as by Freundlich adsorption isotherms. The obtained values are correlated with the parameters characterising the size of molecule, for example, the number of carbon atoms on carbamate functional group. The aim of this paper is the study of physico-chemical properties of the chosen compounds, derivatives of 2-hydroxy-3-[2-(4-methoxyphenyl) ethylamino]propyl-4-[(alkoxycarbonyl)amino]benzoates and 2-hydroxy-3-[2-(2-methoxyphenyl)ethylamino]propyl-4-[(alkoxycarbonyl) amino]benzoates with potential ultra-short beta-adrenolytic activity. The studied compounds are different in the position of the substituent on the benzene ring in the side chain as well as in the aromatic ring in position 4 with alkyl- (methyl-to butyl-) carbamate. The physico-chemical characteristics, for example, lipophilicity, surface activity, adsorbability, acidobasic properties etc., are very important for the explanation of the relationship between structure and biological activity of the drug. These parameters serve as the base of quantitative structure-activity study. The goal of this work is to establish the spectral characteristics of studied compounds in UV-area, pKa values, the parameters of lipophilicity (the values of Rf and RM from thin layer chromatography, retention time t'R and capacity factor k' from liquid chromatography and experimental partition coefficients log P' values), surface tension, critical micelle concentrations, the adsorbability of compounds expressed by percent of adsorbed compound on active charcoal beta% as well as by Freundlich adsorption isotherms. The obtained values are correlated with the parameters characterising the size of molecule, for example, the number of carbon atoms on carbamate functional group.
dcterms:title
Study of physico-chemical properties of potential beta-adrenolytics Study of physico-chemical properties of potential beta-adrenolytics
skos:prefLabel
Study of physico-chemical properties of potential beta-adrenolytics Study of physico-chemical properties of potential beta-adrenolytics
skos:notation
RIV/62157124:16370/14:43873200!RIV15-MSM-16370___
n3:aktivita
n12:V
n3:aktivity
V
n3:cisloPeriodika
2
n3:dodaniDat
n13:2015
n3:domaciTvurceVysledku
n5:8728968 n5:7985479
n3:druhVysledku
n18:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n15:predkladatel
n3:idSjednocenehoVysledku
48318
n3:idVysledku
RIV/62157124:16370/14:43873200
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Ultra-short-acting beta-blockers; Lipophilicity; Critical micelle concentration; Adsorbability
n3:klicoveSlovo
n8:Ultra-short-acting%20beta-blockers n8:Adsorbability n8:Lipophilicity n8:Critical%20micelle%20concentration
n3:kodStatuVydavatele
SK - Slovenská republika
n3:kontrolniKodProRIV
[856C29AE2B0F]
n3:nazevZdroje
Acta Facultatis Pharmaceuticae Universitatis Comenianae Bratislava
n3:obor
n4:FR
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n13:2014
n3:svazekPeriodika
61
n3:tvurceVysledku
Mokrý, Petr Stankovičová, Mária Csöllei, Jozef Kočík, M. Salát, P. Bezáková, Želmíra
s:issn
0301-2298
s:numberOfPages
6
n10:doi
10.2478/afpuc-2014-0014
n14:organizacniJednotka
16370