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Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F14%3A43873139%21RIV15-MSM-16370___
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Motherwort (Leonurus cardiaca) possesses antibacterial, antioxidant, anti-inflammatory, and analgesic activities, and is used as a complementary remedy to improve heart function and blood circulation. Since cardiovascular diseases are often associated with an alteration of mitochondria, the main producers of ATP in cardiac muscle cells, the aim of work was to determine bioactive constituents present in motherwort aerial parts extract in ethanol and investigate their effects on the functions of cardiac mitochondria. The results showed that constituents (chlorogenic acid, orientin, quercetin, hyperoside, and rutin) of L.cardiaca herb extract uncouple (by 20-90%) mitochondrial oxidation from phosphorylation, partially inhibit (by similar to 40%) the mitochondrial respiratory chain in cases of pyruvate and malate as well as succinate oxidation, and effectively attenuate the generation of free radicals in mitochondria. Motherwort (Leonurus cardiaca) possesses antibacterial, antioxidant, anti-inflammatory, and analgesic activities, and is used as a complementary remedy to improve heart function and blood circulation. Since cardiovascular diseases are often associated with an alteration of mitochondria, the main producers of ATP in cardiac muscle cells, the aim of work was to determine bioactive constituents present in motherwort aerial parts extract in ethanol and investigate their effects on the functions of cardiac mitochondria. The results showed that constituents (chlorogenic acid, orientin, quercetin, hyperoside, and rutin) of L.cardiaca herb extract uncouple (by 20-90%) mitochondrial oxidation from phosphorylation, partially inhibit (by similar to 40%) the mitochondrial respiratory chain in cases of pyruvate and malate as well as succinate oxidation, and effectively attenuate the generation of free radicals in mitochondria.
dcterms:title
The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart
skos:prefLabel
The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart
skos:notation
RIV/62157124:16370/14:43873139!RIV15-MSM-16370___
n3:aktivita
n10:S
n3:aktivity
S
n3:cisloPeriodika
7
n3:dodaniDat
n17:2015
n3:domaciTvurceVysledku
n15:7777434
n3:druhVysledku
n7:J
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
13375
n3:idVysledku
RIV/62157124:16370/14:43873139
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Leonurus cardiaca, Lamiaceae, flavonoid, polyphenol, oxidative phosphorylation, cardiac mitochondria
n3:klicoveSlovo
n6:cardiac%20mitochondria n6:oxidative%20phosphorylation n6:Leonurus%20cardiaca n6:polyphenol n6:flavonoid n6:Lamiaceae
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[5D7A23333021]
n3:nazevZdroje
Planta Medica
n3:obor
n16:FR
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
10
n3:rokUplatneniVysledku
n17:2014
n3:svazekPeriodika
80
n3:tvurceVysledku
Kopustinskiene, Dalia Marija Masteiková, Ruta Kuršvietiene, Lolita Trumbeckaite, Sonata Baniene, Rasa Toleikis, Adolfas Jakstas, Valdas Majiene, Daiva Bernatoniene, Jurga Savickas, Arunas
n3:wos
000336493000001
s:issn
0032-0943
s:numberOfPages
8
n11:doi
10.1055/s-0034-1368426
n12:organizacniJednotka
16370