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Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F14%3A43872995%21RIV15-MSM-16370___
rdf:type
skos:Concept n12:Vysledek
rdfs:seeAlso
http://biomed.papers.upol.cz/getrevsrc.php?identification=public&mag=bio&raid=945&type=fin&ver=2
dcterms:description
Background: There is a growing interest in metabolic alterations in patients with psychiatric disorders due to their increased risk for metabolic syndrome (MetS) development. Inflammation is known to underlie the pathophysiology of schizophrenia and depression as well as MetS. Vulnerability factors for schizophrenia/depression and MetS hence appear to be shared. Methods and Results: Based on a Web of Science search, this review examines current evidence for MetS pathophysiology involving dysregulation of adipose tissue signaling - adipokines and pro-inflammatory cytokine, both also known to be aberrant in schizophrenia/depression. Further, gender differences in the incidence and course of schizophrenia/depression were reported. The disturbances linked to the MetS are also described. Therefore, this review further maps the gender differences in the psychiatric-metabolic comorbidities. Conclusion: There is evidence supporting a pathological predisposition to MetS in both schizophrenia and depression in both humans and animal models. This predisposition is dramatically enhanced by antipsychotic medication. Further, there are gender differences from clinical findings suggesting women with schizophrenia/depression are more vulnerable to MetS development. This has not yet been assessed in animal studies. We suggest further validation of existing schizophrenia and depression animal models for the assessment of metabolic disturbances to provide tools for developing new antipsychotics and antidepressants with %22metabolically inert%22 profile or improving the metabolic status in schizophrenic/depressed patients. Background: There is a growing interest in metabolic alterations in patients with psychiatric disorders due to their increased risk for metabolic syndrome (MetS) development. Inflammation is known to underlie the pathophysiology of schizophrenia and depression as well as MetS. Vulnerability factors for schizophrenia/depression and MetS hence appear to be shared. Methods and Results: Based on a Web of Science search, this review examines current evidence for MetS pathophysiology involving dysregulation of adipose tissue signaling - adipokines and pro-inflammatory cytokine, both also known to be aberrant in schizophrenia/depression. Further, gender differences in the incidence and course of schizophrenia/depression were reported. The disturbances linked to the MetS are also described. Therefore, this review further maps the gender differences in the psychiatric-metabolic comorbidities. Conclusion: There is evidence supporting a pathological predisposition to MetS in both schizophrenia and depression in both humans and animal models. This predisposition is dramatically enhanced by antipsychotic medication. Further, there are gender differences from clinical findings suggesting women with schizophrenia/depression are more vulnerable to MetS development. This has not yet been assessed in animal studies. We suggest further validation of existing schizophrenia and depression animal models for the assessment of metabolic disturbances to provide tools for developing new antipsychotics and antidepressants with %22metabolically inert%22 profile or improving the metabolic status in schizophrenic/depressed patients.
dcterms:title
The common pathophysiology underlying the metabolic syndrome, schizophrenia and depression. A review. The common pathophysiology underlying the metabolic syndrome, schizophrenia and depression. A review.
skos:prefLabel
The common pathophysiology underlying the metabolic syndrome, schizophrenia and depression. A review. The common pathophysiology underlying the metabolic syndrome, schizophrenia and depression. A review.
skos:notation
RIV/62157124:16370/14:43872995!RIV15-MSM-16370___
n3:aktivita
n13:S
n3:aktivity
S
n3:cisloPeriodika
December
n3:dodaniDat
n14:2015
n3:domaciTvurceVysledku
n7:4203860 n7:2375168
n3:druhVysledku
n16:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
7865
n3:idVysledku
RIV/62157124:16370/14:43872995
n3:jazykVysledku
n10:eng
n3:klicovaSlova
AFABP; resistin; adiponectin; leptin; adipokines; gender differences; sex; depression; schizophrenia; metabolic syndrome
n3:klicoveSlovo
n4:gender%20differences n4:metabolic%20syndrome n4:resistin n4:AFABP n4:adipokines n4:adiponectin n4:depression n4:schizophrenia n4:sex n4:leptin
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[6D17163793E6]
n3:nazevZdroje
Biomedical Papers Faculty of Medicine of Palacky University Olomouc
n3:obor
n17:FB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n14:2014
n3:svazekPeriodika
158
n3:tvurceVysledku
Kučerová, Jana Babinská, Zuzana Horská, Kateřina Kotolová, Hana
s:issn
1213-8118
s:numberOfPages
7
n15:doi
10.5507/bp.2014.060
n6:organizacniJednotka
16370