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Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F13%3A43872229%21RIV14-MSM-16370___
rdf:type
n9:Vysledek skos:Concept
dcterms:description
Development of new pharmaceutical compounds and dosage forms often requires in vitro dissolution testing with the closest similarity to the human gastrointestinal (GI) tract. To create such conditions, one needs a suitable dissolution apparatus and the appropriate data on the human GI physiology. This review discusses technological approaches applicable in biorelevant dissolutions as well as the physiology of stomach and small intestine in both fasted and fed state, that is, volumes of contents, transit times for water/food and various solid oral dosage forms, pH, osmolality, surface tension, buffer capacity, and concentrations of bile salts, phospholipids, enzymes, and Ca2+ ions. The information is aimed to provide clear suggestions on how these conditions should be set in a dynamic biorelevant dissolution test. (C) 2013 Wiley Periodicals, Inc. and the American Pharmacists Association Development of new pharmaceutical compounds and dosage forms often requires in vitro dissolution testing with the closest similarity to the human gastrointestinal (GI) tract. To create such conditions, one needs a suitable dissolution apparatus and the appropriate data on the human GI physiology. This review discusses technological approaches applicable in biorelevant dissolutions as well as the physiology of stomach and small intestine in both fasted and fed state, that is, volumes of contents, transit times for water/food and various solid oral dosage forms, pH, osmolality, surface tension, buffer capacity, and concentrations of bile salts, phospholipids, enzymes, and Ca2+ ions. The information is aimed to provide clear suggestions on how these conditions should be set in a dynamic biorelevant dissolution test. (C) 2013 Wiley Periodicals, Inc. and the American Pharmacists Association
dcterms:title
Designing a Dynamic Dissolution Method: A Review of Instrumental Options and Corresponding Physiology of Stomach and Small Intestine Designing a Dynamic Dissolution Method: A Review of Instrumental Options and Corresponding Physiology of Stomach and Small Intestine
skos:prefLabel
Designing a Dynamic Dissolution Method: A Review of Instrumental Options and Corresponding Physiology of Stomach and Small Intestine Designing a Dynamic Dissolution Method: A Review of Instrumental Options and Corresponding Physiology of Stomach and Small Intestine
skos:notation
RIV/62157124:16370/13:43872229!RIV14-MSM-16370___
n9:predkladatel
n11:orjk%3A16370
n3:aktivita
n19:S
n3:aktivity
S
n3:cisloPeriodika
9
n3:dodaniDat
n15:2014
n3:domaciTvurceVysledku
n7:4310683 n7:9033793 n7:1462245
n3:druhVysledku
n16:J
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
68665
n3:idVysledku
RIV/62157124:16370/13:43872229
n3:jazykVysledku
n4:eng
n3:klicovaSlova
bioavailability; bioequivalence; in vitro models; dissolution; gastrointestinal transit; biorelevant dissolution; gastrointestinal physiology; dynamic dissolution
n3:klicoveSlovo
n10:bioequivalence n10:dissolution n10:biorelevant%20dissolution n10:dynamic%20dissolution n10:gastrointestinal%20physiology n10:gastrointestinal%20transit n10:in%20vitro%20models n10:bioavailability
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[34B4AC6259CC]
n3:nazevZdroje
Journal of Pharmaceutical sciences
n3:obor
n14:FR
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n15:2013
n3:svazekPeriodika
102
n3:tvurceVysledku
Jampílek, Josef Dohnal, Jiří Čulen, Martin Řezáčová, Anna
n3:wos
000330240900011
s:issn
0022-3549
s:numberOfPages
23
n17:doi
10.1002/jps.23494
n5:organizacniJednotka
16370