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Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F13%3A43871783%21RIV14-MSM-16370___
rdf:type
n8:Vysledek skos:Concept
rdfs:seeAlso
http://www.hindawi.com/journals/ecam/2013/350519/
dcterms:description
Morus alba L. (MA) is a natural source of many compounds with different biological effects. It has been described to possess anti-inflammatory, antioxidant, and hepatoprotective activities. The aim of this study was to evaluate cytotoxicity of three flavonoids isolated from MA(kuwanon E, cudraflavone B, and 4'-O-methylkuwanon E) and to determine their effects on proliferation of THP-1 cells, and on cell cycle progression of cancer cells. Anti-inflammatory effects were also determined for all three given flavonoids. Methods used in the study included quantification of cells by hemocytometer and WST-1 assays, flow cytometry, western blotting, ELISA, and zymography. From the three compounds tested, cudraflavone B showed the strongest effects on cell cycle progression and viability of tumor and/or immortalized cells and also on inflammatory response of macrophage-like cells. Kuwanon E and 4'-O-methylkuwanon E exerted more sophisticated rather than direct toxic effect on used cell types. Our data indicate that mechanisms different from stress-related or apoptotic signaling pathways are involved in the action of these compounds. Although further studies are required to precisely define the mechanisms of MA flavonoid action in human cancer and macrophage-like cells, here we demonstrate their effects combining antiproliferative and anti-inflammatory activities, respectively Morus alba L. (MA) is a natural source of many compounds with different biological effects. It has been described to possess anti-inflammatory, antioxidant, and hepatoprotective activities. The aim of this study was to evaluate cytotoxicity of three flavonoids isolated from MA(kuwanon E, cudraflavone B, and 4'-O-methylkuwanon E) and to determine their effects on proliferation of THP-1 cells, and on cell cycle progression of cancer cells. Anti-inflammatory effects were also determined for all three given flavonoids. Methods used in the study included quantification of cells by hemocytometer and WST-1 assays, flow cytometry, western blotting, ELISA, and zymography. From the three compounds tested, cudraflavone B showed the strongest effects on cell cycle progression and viability of tumor and/or immortalized cells and also on inflammatory response of macrophage-like cells. Kuwanon E and 4'-O-methylkuwanon E exerted more sophisticated rather than direct toxic effect on used cell types. Our data indicate that mechanisms different from stress-related or apoptotic signaling pathways are involved in the action of these compounds. Although further studies are required to precisely define the mechanisms of MA flavonoid action in human cancer and macrophage-like cells, here we demonstrate their effects combining antiproliferative and anti-inflammatory activities, respectively
dcterms:title
Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1/S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1/S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response
skos:prefLabel
Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1/S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response Prenylated Flavonoids from Morus alba L. Cause Inhibition of G1/S Transition in THP-1 Human Leukemia Cells and Prevent the Lipopolysaccharide-Induced Inflammatory Response
skos:notation
RIV/62157124:16370/13:43871783!RIV14-MSM-16370___
n8:predkladatel
n9:orjk%3A16370
n3:aktivita
n5:S n5:P n5:Z n5:I
n3:aktivity
I, P(ED1.100/02/0123), S, Z(MSM0021622430)
n3:cisloPeriodika
20. května
n3:dodaniDat
n12:2014
n3:domaciTvurceVysledku
n4:4091647 n4:8089736 n4:5062926 n4:4373510 n4:4281888
n3:druhVysledku
n10:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
98933
n3:idVysledku
RIV/62157124:16370/13:43871783
n3:jazykVysledku
n21:eng
n3:klicovaSlova
Flavonoids, Morus alba, Cytostatic effect, Cytotoxicity, Cell cycle, Inflammation
n3:klicoveSlovo
n11:Cell%20cycle n11:Cytostatic%20effect n11:Cytotoxicity n11:Inflammation n11:Morus%20alba n11:Flavonoids
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[E57028523B32]
n3:nazevZdroje
Evidence-based complementary and alternative medicine : eCAM
n3:obor
n13:FR
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
10
n3:projekt
n16:ED1.100%2F02%2F0123
n3:rokUplatneniVysledku
n12:2013
n3:svazekPeriodika
Neuveden
n3:tvurceVysledku
Suchý, Pavel Hampl, Aleš Závalová, Veronika Souček, Karel Šmejkal, Karel Talhouk, Rabih Hošek, Jan Kollár, Peter Bárta, Tomáš Artinian, Shushan
n3:wos
000319928000001
n3:zamer
n6:MSM0021622430
s:issn
1741-427X
s:numberOfPages
13
n22:doi
10.1155/2013/350519
n20:organizacniJednotka
16370