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Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F12%3A43871636%21RIV13-MSM-16370___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
The aim of this work is the study of stability and kinetics of hydrolysis of the chosen compounds, derivatives of 2-hydroxy-3-[2-(4-methoxyphenyl)ethylamino]propyl-4- [(alkoxycarbonyl)amino]benzoates and 2-hydroxy-3-[2-(2-methoxyphenyl)ethylamino] propyl-4-[(alkoxycarbonyl)amino]benzoates with potential ultra-short beta-adrenolytic activity. The studied compounds are different in the position of the substituent on the benzene ring in the side chain as well as in the aromatic ring in position 4 with alkyl- (methyl- to butyl-) carbamate. Thin layer chromatography and UV-area spectrophotometry are used in order to establish the stability of these potential pharmaceuticals. The stability studies of the compounds were examined in acidic and alkaline media, in buffers and due oxidation at room and at elevated temperature chromatographically, and Rf values of incipient products and degradation products were detected. Kinetics of acid and base hydrolysis in various solutions at temperatures 80 °C and 100 °C were examined through UV-area spectrophotometry. Kinetic parameters such as rate constant k, half-life period t1/2 and usable life t90 were determined. The aim of this work is the study of stability and kinetics of hydrolysis of the chosen compounds, derivatives of 2-hydroxy-3-[2-(4-methoxyphenyl)ethylamino]propyl-4- [(alkoxycarbonyl)amino]benzoates and 2-hydroxy-3-[2-(2-methoxyphenyl)ethylamino] propyl-4-[(alkoxycarbonyl)amino]benzoates with potential ultra-short beta-adrenolytic activity. The studied compounds are different in the position of the substituent on the benzene ring in the side chain as well as in the aromatic ring in position 4 with alkyl- (methyl- to butyl-) carbamate. Thin layer chromatography and UV-area spectrophotometry are used in order to establish the stability of these potential pharmaceuticals. The stability studies of the compounds were examined in acidic and alkaline media, in buffers and due oxidation at room and at elevated temperature chromatographically, and Rf values of incipient products and degradation products were detected. Kinetics of acid and base hydrolysis in various solutions at temperatures 80 °C and 100 °C were examined through UV-area spectrophotometry. Kinetic parameters such as rate constant k, half-life period t1/2 and usable life t90 were determined.
dcterms:title
Evaluation of Stability of Potential Betaadrenolytics in Various Solutions by thin Layer Chromatography and by Kinetics of Hydrolysis Evaluation of Stability of Potential Betaadrenolytics in Various Solutions by thin Layer Chromatography and by Kinetics of Hydrolysis
skos:prefLabel
Evaluation of Stability of Potential Betaadrenolytics in Various Solutions by thin Layer Chromatography and by Kinetics of Hydrolysis Evaluation of Stability of Potential Betaadrenolytics in Various Solutions by thin Layer Chromatography and by Kinetics of Hydrolysis
skos:notation
RIV/62157124:16370/12:43871636!RIV13-MSM-16370___
n14:predkladatel
n15:orjk%3A16370
n3:aktivita
n19:V
n3:aktivity
V
n3:cisloPeriodika
2
n3:dodaniDat
n10:2013
n3:domaciTvurceVysledku
n4:7985479 n4:8728968 n4:5532795
n3:druhVysledku
n17:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
135184
n3:idVysledku
RIV/62157124:16370/12:43871636
n3:jazykVysledku
n16:eng
n3:klicovaSlova
kinetics of hydrolysis; stability study; ultra short acting beta-blockers
n3:klicoveSlovo
n9:kinetics%20of%20hydrolysis n9:stability%20study n9:ultra%20short%20acting%20beta-blockers
n3:kodStatuVydavatele
SK - Slovenská republika
n3:kontrolniKodProRIV
[4BCD50AB9680]
n3:nazevZdroje
Acta Facultatis Pharmaceuticae Universitatis Comenianae Bratislava
n3:obor
n18:FR
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n10:2012
n3:svazekPeriodika
59
n3:tvurceVysledku
Csöllei, Jozef Stankovičová, Mária Dvořáková-Kotlíková, Silvie Liptáková, B. Pažitná, M. Mokrý, Petr Bezáková, Ž. Ševčíková, Zuzana
s:issn
0301-2298
s:numberOfPages
9
n5:doi
10.2478/v10219-012-0025-5
n11:organizacniJednotka
16370