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Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F12%3A43871258%21RIV13-MSM-16370___
rdf:type
n3:Vysledek skos:Concept
dcterms:description
Hot-melt extrusion (HME), originally coming from plastic industry, becomes at present an interesting technology also in the pharmaceutical field. The number of drugs with poor solubility and also bioavailability is increasing. In addition, most of the organic drugs are exhibiting polymorphism. Together with the utilization of appropriate carriers and other excipients, HME introduces an interesting possibility how to increase the solubility of poorly soluble drugs or protect unwanted polymorphic changes and how to improve bioavailability of problematic drugs. HME can also be used in the formation of dosage forms with controlled drug release, e.g. pellets or films. It is a relative inexpensive, efficient and reproducible technology, a solvent free and drug-friendly process. This article is an overview of possible utilization of this modern technology in the pharmaceutical field. Hot-melt extrusion (HME), originally coming from plastic industry, becomes at present an interesting technology also in the pharmaceutical field. The number of drugs with poor solubility and also bioavailability is increasing. In addition, most of the organic drugs are exhibiting polymorphism. Together with the utilization of appropriate carriers and other excipients, HME introduces an interesting possibility how to increase the solubility of poorly soluble drugs or protect unwanted polymorphic changes and how to improve bioavailability of problematic drugs. HME can also be used in the formation of dosage forms with controlled drug release, e.g. pellets or films. It is a relative inexpensive, efficient and reproducible technology, a solvent free and drug-friendly process. This article is an overview of possible utilization of this modern technology in the pharmaceutical field.
dcterms:title
Hot-melt extrusion Hot-melt extrusion
skos:prefLabel
Hot-melt extrusion Hot-melt extrusion
skos:notation
RIV/62157124:16370/12:43871258!RIV13-MSM-16370___
n3:predkladatel
n15:orjk%3A16370
n4:aktivita
n18:S
n4:aktivity
S
n4:cisloPeriodika
3
n4:dodaniDat
n7:2013
n4:domaciTvurceVysledku
n16:3102521
n4:druhVysledku
n5:J
n4:duvernostUdaju
n17:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
139643
n4:idVysledku
RIV/62157124:16370/12:43871258
n4:jazykVysledku
n9:eng
n4:klicovaSlova
hot-melt extrusion, equipment, excipients, pellets, films
n4:klicoveSlovo
n8:hot-melt%20extrusion n8:excipients n8:equipment n8:pellets n8:films
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[2780BF53D4BA]
n4:nazevZdroje
Česká a slovenská farmacie
n4:obor
n11:FR
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
2
n4:rokUplatneniVysledku
n7:2012
n4:svazekPeriodika
61
n4:tvurceVysledku
Šalandová, Jana Rabišková, Miloslava
s:issn
1210-7816
s:numberOfPages
6
n13:organizacniJednotka
16370