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Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F12%3A43871087%21RIV13-MSM-16370___
rdf:type
skos:Concept n3:Vysledek
dcterms:description
Series of new ring-substituted styrylquinolines and two oxorhenium complexes were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against fungal and bacterial strains. Some compounds were active against bacteria at micromolar level and against fungi at submicromolar level. Compounds 5,7-dichloro-2-[2-(2-ethoxyphenyl)vinyl]quinolin-8-ol expressed excellent antifungal activity comparable with or higher than the standard fluconazole as well as antibacterial activity against Staphylococcus strains comparable with or higher than the standards bacitracin, penicillin and ciprofloxacin. The structure-activity relationships are discussed. (C) 2012 Elsevier Ltd. All rights reserved. Series of new ring-substituted styrylquinolines and two oxorhenium complexes were prepared and characterized. The compounds were analyzed using RP-HPLC to determine lipophilicity. Primary in vitro screening of the synthesized compounds was performed against fungal and bacterial strains. Some compounds were active against bacteria at micromolar level and against fungi at submicromolar level. Compounds 5,7-dichloro-2-[2-(2-ethoxyphenyl)vinyl]quinolin-8-ol expressed excellent antifungal activity comparable with or higher than the standard fluconazole as well as antibacterial activity against Staphylococcus strains comparable with or higher than the standards bacitracin, penicillin and ciprofloxacin. The structure-activity relationships are discussed. (C) 2012 Elsevier Ltd. All rights reserved.
dcterms:title
Contribution to investigation of antimicrobial activity of styrylquinolines Contribution to investigation of antimicrobial activity of styrylquinolines
skos:prefLabel
Contribution to investigation of antimicrobial activity of styrylquinolines Contribution to investigation of antimicrobial activity of styrylquinolines
skos:notation
RIV/62157124:16370/12:43871087!RIV13-MSM-16370___
n3:predkladatel
n4:orjk%3A16370
n5:aktivita
n11:V n11:I
n5:aktivity
I, V
n5:cisloPeriodika
24
n5:dodaniDat
n19:2013
n5:domaciTvurceVysledku
n9:9033793
n5:druhVysledku
n16:J
n5:duvernostUdaju
n6:S
n5:entitaPredkladatele
n12:predkladatel
n5:idSjednocenehoVysledku
128658
n5:idVysledku
RIV/62157124:16370/12:43871087
n5:jazykVysledku
n18:eng
n5:klicovaSlova
Structure-activity relationships; In vitro antibacterial activity; In vitro antifungal activity; Quinolines lipophilicity
n5:klicoveSlovo
n7:In%20vitro%20antibacterial%20activity n7:Structure-activity%20relationships n7:Quinolines%20lipophilicity n7:In%20vitro%20antifungal%20activity
n5:kodStatuVydavatele
NL - Nizozemsko
n5:kontrolniKodProRIV
[E0231D32C48B]
n5:nazevZdroje
Bioorganic and Medicinal Chemistry
n5:obor
n10:FR
n5:pocetDomacichTvurcuVysledku
1
n5:pocetTvurcuVysledku
8
n5:rokUplatneniVysledku
n19:2012
n5:svazekPeriodika
20
n5:tvurceVysledku
Musiol, Robert Jampílek, Josef Nycz, Jacek E Polanski, Jaroslaw Wolff, Mariusz Cieslik, Wioleta Machura, Barbara Vejšová, Marcela
n5:wos
000311421300007
s:issn
0968-0896
s:numberOfPages
9
n13:doi
10.1016/j.bmc.2012.10.027
n17:organizacniJednotka
16370