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Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F12%3A43871080%21RIV13-MZ0-16370___
rdf:type
skos:Concept n6:Vysledek
dcterms:description
Preparation of coated pellets intended for rutin colon delivery, their evaluation in vitro and in vivo in experimental colitis in rats was the purpose of this study. Pellets were obtained using extrusion/spheronization and coated with three types of coatings (caffeic acid/hypromellose/alginic acid; sodium alginate/hypromellose/zinc acetate; sodium alginate/chitosan). Dissolution using buffers of pH values, beta-glucosidase and times corresponding to gastrointestinal tract (GIT) was provided. Pellets coated with alginate/chitosan showed low rutin dissolution (12-14%) in upper GIT conditions and fast release (87-89%) under colon conditions; that is a good presumption of intended rutin release. After colitis induction and development, the rats were treated with pellets and rutin solution administered orally, solution also rectally. Colon/body weight ratio, myeloperoxidase activity and histological evaluation were performed. Rutin was able to promote colonic healing at the dose of 10mg/kg: colon/body weight ratio decreased and myeloperoxidase activity was significantly suppressed. Pellets coated with alginate/chitosan applied orally and rutin solution administered rectally showed the best efficacy. The combination of rutin as natural product, mucoadhesive chitosan degraded in the colon and sodium alginate as the main coating substance in the form of pellets create a promising preparation for therapy of this severe illness. Preparation of coated pellets intended for rutin colon delivery, their evaluation in vitro and in vivo in experimental colitis in rats was the purpose of this study. Pellets were obtained using extrusion/spheronization and coated with three types of coatings (caffeic acid/hypromellose/alginic acid; sodium alginate/hypromellose/zinc acetate; sodium alginate/chitosan). Dissolution using buffers of pH values, beta-glucosidase and times corresponding to gastrointestinal tract (GIT) was provided. Pellets coated with alginate/chitosan showed low rutin dissolution (12-14%) in upper GIT conditions and fast release (87-89%) under colon conditions; that is a good presumption of intended rutin release. After colitis induction and development, the rats were treated with pellets and rutin solution administered orally, solution also rectally. Colon/body weight ratio, myeloperoxidase activity and histological evaluation were performed. Rutin was able to promote colonic healing at the dose of 10mg/kg: colon/body weight ratio decreased and myeloperoxidase activity was significantly suppressed. Pellets coated with alginate/chitosan applied orally and rutin solution administered rectally showed the best efficacy. The combination of rutin as natural product, mucoadhesive chitosan degraded in the colon and sodium alginate as the main coating substance in the form of pellets create a promising preparation for therapy of this severe illness.
dcterms:title
Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: In vitro characteristics and in vivo evaluation Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: In vitro characteristics and in vivo evaluation
skos:prefLabel
Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: In vitro characteristics and in vivo evaluation Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: In vitro characteristics and in vivo evaluation
skos:notation
RIV/62157124:16370/12:43871080!RIV13-MZ0-16370___
n6:predkladatel
n7:orjk%3A16370
n3:aktivita
n12:Z n12:I n12:P
n3:aktivity
I, P(NS10222), Z(MSM0021620822)
n3:cisloPeriodika
1-2
n3:dodaniDat
n16:2013
n3:domaciTvurceVysledku
n10:3102521 n10:5865786 n10:8692025 n10:1212001
n3:druhVysledku
n15:J
n3:duvernostUdaju
n9:S
n3:entitaPredkladatele
n21:predkladatel
n3:idSjednocenehoVysledku
127577
n3:idVysledku
RIV/62157124:16370/12:43871080
n3:jazykVysledku
n18:eng
n3:klicovaSlova
colonic delivery, coated pellets, rutin, chitosan, in vitro characteristics, in vivo evaluation
n3:klicoveSlovo
n4:rutin n4:colonic%20delivery n4:chitosan n4:in%20vitro%20characteristics n4:in%20vivo%20evaluation n4:coated%20pellets
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[8F3ED6577A2F]
n3:nazevZdroje
International Journal of Pharmaceutics
n3:obor
n11:FR
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
7
n3:projekt
n19:NS10222
n3:rokUplatneniVysledku
n16:2012
n3:svazekPeriodika
422
n3:tvurceVysledku
Rabišková, Miloslava Lamprecht, Alf Gajdziok, Jan Pellequer, Yann Spilková, Jiřina Dvořáčková, Kateřina Bautzová, Tereza
n3:wos
000302398700019
n3:zamer
n20:MSM0021620822
s:issn
0378-5173
s:numberOfPages
9
n8:doi
10.1016/j.ijpharm.2011.10.045
n14:organizacniJednotka
16370