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Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F11%3A43870772%21RIV12-MSM-16370___
rdf:type
n10:Vysledek skos:Concept
dcterms:description
This work deals with the study of the stability of six derivatives of the [(arylcarbonyl)oxy]amino propanol with carbamate substitution on the benzene ring. The studied compounds are different in the substitution on the amine group in the side chain as well as in the substitution on the carbamate functional group. The hydrolysis of compounds was measured in the aqueous-ethanol sodium hydroxide solution (0.1 mol.l-1) at 25, 37, 45 and 60 °C spectrophotometrically in the ultraviolet and visual regions. The studied compounds possess two functional groups, which undergo hydrolysis. The pseudo-first order rate constants of hydrolysis for individual reaction steps were determined. The ester functional group of compounds hydrolyses very quickly in this medium. The compounds possessing the tertiary substitution on the amino group are less stable toward alkaline hydrolysis. The course of hydrolysis of compounds was also investigated by thin layer chromatography (TLC). This work deals with the study of the stability of six derivatives of the [(arylcarbonyl)oxy]amino propanol with carbamate substitution on the benzene ring. The studied compounds are different in the substitution on the amine group in the side chain as well as in the substitution on the carbamate functional group. The hydrolysis of compounds was measured in the aqueous-ethanol sodium hydroxide solution (0.1 mol.l-1) at 25, 37, 45 and 60 °C spectrophotometrically in the ultraviolet and visual regions. The studied compounds possess two functional groups, which undergo hydrolysis. The pseudo-first order rate constants of hydrolysis for individual reaction steps were determined. The ester functional group of compounds hydrolyses very quickly in this medium. The compounds possessing the tertiary substitution on the amino group are less stable toward alkaline hydrolysis. The course of hydrolysis of compounds was also investigated by thin layer chromatography (TLC).
dcterms:title
Study of stability of potential beta-adrenolytics, derivatives of the [(arylcarbonyl)oxy]aminopropanol by kinetics of alkaline hydrolysis Study of stability of potential beta-adrenolytics, derivatives of the [(arylcarbonyl)oxy]aminopropanol by kinetics of alkaline hydrolysis
skos:prefLabel
Study of stability of potential beta-adrenolytics, derivatives of the [(arylcarbonyl)oxy]aminopropanol by kinetics of alkaline hydrolysis Study of stability of potential beta-adrenolytics, derivatives of the [(arylcarbonyl)oxy]aminopropanol by kinetics of alkaline hydrolysis
skos:notation
RIV/62157124:16370/11:43870772!RIV12-MSM-16370___
n10:predkladatel
n17:orjk%3A16370
n3:aktivita
n5:I
n3:aktivity
I
n3:cisloPeriodika
1
n3:dodaniDat
n18:2012
n3:domaciTvurceVysledku
n8:7985479 n8:8728968
n3:druhVysledku
n12:J
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
233120
n3:idVysledku
RIV/62157124:16370/11:43870772
n3:jazykVysledku
n19:eng
n3:klicovaSlova
kinetics of hydrolysis; stability; ultra short acting beta-adrenolytics
n3:klicoveSlovo
n11:stability n11:kinetics%20of%20hydrolysis n11:ultra%20short%20acting%20beta-adrenolytics
n3:kodStatuVydavatele
SK - Slovenská republika
n3:kontrolniKodProRIV
[92CF06FD53C9]
n3:nazevZdroje
Acta Facultatis Pharmaceuticae Universitatis Comenianae Bratislava
n3:obor
n6:FR
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
7
n3:rokUplatneniVysledku
n18:2011
n3:svazekPeriodika
58
n3:tvurceVysledku
Bezáková, Želmíra Mokrý, Petr Mažeriková, J. Stankovičová, Mária Kissová, M. Csöllei, Jozef Pavlíková, J.
s:issn
0301-2298
s:numberOfPages
9
n4:doi
10.2478/v10219-011-0008-y
n13:organizacniJednotka
16370