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Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F11%3A43870397%21RIV12-MSM-16370___
rdf:type
n6:Vysledek skos:Concept
dcterms:description
The aim of the study was to prepare pellets of maidenhair tree (Ginkgo biloba), motherwort (Leonurus cardiaca) and hawthorn (Crataegus monogyna) dry extracts by extrusion/spheronization method. The critical step of this process was the amount of added wetting liquid (water-ethanolic mixture) and the amount of extract in the formulation. The samples of pellets containing 30-50% of extracts were formulated: pellets contained extracts of Ginkgo, Crataegi and Leonuri. The last sample was aimed to the formulation of pellets with the content of 30% of the mixture of Ginkgo, Leonuri and Crataegi extracts in the ratio of 1:5:6. The remainder of the solid compounds in all formulations was microcrystalline cellulose (Avicel PH-101). It was not possible to find a way to adequately wetting of the formulations with the content of extracts higher than 30% because of the unsuitable properties of all three extracts used. On the basis of the experiments, pellets with mixtures of all three previously used extracts were prepared. These pellets showed perfect physico-mechanical properties: hardness (10.00 +/- 2.24 N), friability (0.06%), repose angle (20.99 +/- 0.41 degrees), flowability (6.97 +/- 0.29 s/100g of pellets), sphericity (0.81 +/- 0.05), compressibility index (4.65%), intraparticular porosity (0.09%) and interparticular porosity (45.11%), which predetermined them to other testing and usage (feeling into capsules, tableting, coating etc.). The aim of the study was to prepare pellets of maidenhair tree (Ginkgo biloba), motherwort (Leonurus cardiaca) and hawthorn (Crataegus monogyna) dry extracts by extrusion/spheronization method. The critical step of this process was the amount of added wetting liquid (water-ethanolic mixture) and the amount of extract in the formulation. The samples of pellets containing 30-50% of extracts were formulated: pellets contained extracts of Ginkgo, Crataegi and Leonuri. The last sample was aimed to the formulation of pellets with the content of 30% of the mixture of Ginkgo, Leonuri and Crataegi extracts in the ratio of 1:5:6. The remainder of the solid compounds in all formulations was microcrystalline cellulose (Avicel PH-101). It was not possible to find a way to adequately wetting of the formulations with the content of extracts higher than 30% because of the unsuitable properties of all three extracts used. On the basis of the experiments, pellets with mixtures of all three previously used extracts were prepared. These pellets showed perfect physico-mechanical properties: hardness (10.00 +/- 2.24 N), friability (0.06%), repose angle (20.99 +/- 0.41 degrees), flowability (6.97 +/- 0.29 s/100g of pellets), sphericity (0.81 +/- 0.05), compressibility index (4.65%), intraparticular porosity (0.09%) and interparticular porosity (45.11%), which predetermined them to other testing and usage (feeling into capsules, tableting, coating etc.).
dcterms:title
The evaluation of formulations for the preparation of new formula pellets The evaluation of formulations for the preparation of new formula pellets
skos:prefLabel
The evaluation of formulations for the preparation of new formula pellets The evaluation of formulations for the preparation of new formula pellets
skos:notation
RIV/62157124:16370/11:43870397!RIV12-MSM-16370___
n6:predkladatel
n14:orjk%3A16370
n3:aktivita
n18:I n18:S
n3:aktivity
I, S
n3:cisloPeriodika
5
n3:dodaniDat
n12:2012
n3:domaciTvurceVysledku
n7:7777434 n7:8692025 n7:1212001 n7:1449052
n3:druhVysledku
n17:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
198307
n3:idVysledku
RIV/62157124:16370/11:43870397
n3:jazykVysledku
n5:eng
n3:klicovaSlova
crataegus monogyna; leonurus cardiaca; ginkgo biloba; microcrystalline cellulose; extrusion/spheronization
n3:klicoveSlovo
n15:microcrystalline%20cellulose n15:crataegus%20monogyna n15:leonurus%20cardiaca n15:ginkgo%20biloba n15:extrusion%2Fspheronization
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[1927FD3B7C23]
n3:nazevZdroje
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
n3:obor
n19:FR
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n12:2011
n3:svazekPeriodika
16
n3:tvurceVysledku
Petkeviciute, Zivile Dvořáčková, Kateřina Lazauskas, Robertas Bernatoniene, Ruta Muselík, Jan Bernatoniene, Jurga Gajdziok, Jan Masteiková, Ruta Kalveniene, Zenona
n3:wos
000294923600011
s:issn
1083-7450
s:numberOfPages
9
n11:doi
10.3109/10837450.2010.502174
n9:organizacniJednotka
16370