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Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F11%3A43870392%21RIV12-MSM-16370___
rdf:type
n5:Vysledek skos:Concept
dcterms:description
The aim of this study was to develop novel hydrogel-based beads and characterize their potential to deliver and release a drug exhibiting pH-dependent solubility into distal parts of gastrointestinal (GI) tract. Oxycellulose beads containing diclofenac sodium as a model drug were prepared by the ionotropic external gelation technique using calcium chloride solution as the crosslinking medium. Resulting beads were characterized in terms of particle shape and size, encapsulation efficacy, swelling ability and in vitro drug release. Also, potential drug-polymer interactions were evaluated using Fourier transform infrared spectroscopy. The particle size was found to be 0.92-0.96 mm for inactive (oxycellulose only) and 1.47-1.60 mm for active (oxycellulose-diclofenac sodium) beads, respectively. In all cases, the sphericity factor was between 0.70 and 0.81 with higher values observed for samples containing higher polymer and drug concentrations. The swelling of inactive beads was found to be strongly influenced by the pH and composition (i.e. Na+ concentration) of the selected media (simulated gastric fluid vs. phosphate buffer pH 6.8). The encapsulation efficiency of the prepared particles ranged from 58% to 65%. Results of dissolution tests showed that the drug loading inside of the particles influenced the rate of its release. In general, prepared particles were able to release the drug within 12-16 h after a lag time of 4 h. Fickian diffusion was found as the predominant drug release mechanism. Thus, this novel particulate system showed a good potential to deliver drugs specifically to the distal parts of the human GI tract. The aim of this study was to develop novel hydrogel-based beads and characterize their potential to deliver and release a drug exhibiting pH-dependent solubility into distal parts of gastrointestinal (GI) tract. Oxycellulose beads containing diclofenac sodium as a model drug were prepared by the ionotropic external gelation technique using calcium chloride solution as the crosslinking medium. Resulting beads were characterized in terms of particle shape and size, encapsulation efficacy, swelling ability and in vitro drug release. Also, potential drug-polymer interactions were evaluated using Fourier transform infrared spectroscopy. The particle size was found to be 0.92-0.96 mm for inactive (oxycellulose only) and 1.47-1.60 mm for active (oxycellulose-diclofenac sodium) beads, respectively. In all cases, the sphericity factor was between 0.70 and 0.81 with higher values observed for samples containing higher polymer and drug concentrations. The swelling of inactive beads was found to be strongly influenced by the pH and composition (i.e. Na+ concentration) of the selected media (simulated gastric fluid vs. phosphate buffer pH 6.8). The encapsulation efficiency of the prepared particles ranged from 58% to 65%. Results of dissolution tests showed that the drug loading inside of the particles influenced the rate of its release. In general, prepared particles were able to release the drug within 12-16 h after a lag time of 4 h. Fickian diffusion was found as the predominant drug release mechanism. Thus, this novel particulate system showed a good potential to deliver drugs specifically to the distal parts of the human GI tract.
dcterms:title
Oxycellulose Beads with Drug Exhibiting pH-Dependent Solubility Oxycellulose Beads with Drug Exhibiting pH-Dependent Solubility
skos:prefLabel
Oxycellulose Beads with Drug Exhibiting pH-Dependent Solubility Oxycellulose Beads with Drug Exhibiting pH-Dependent Solubility
skos:notation
RIV/62157124:16370/11:43870392!RIV12-MSM-16370___
n5:predkladatel
n8:orjk%3A16370
n3:aktivita
n6:S n6:P n6:I
n3:aktivity
I, P(2A-1TP1/073), S
n3:cisloPeriodika
4
n3:dodaniDat
n15:2012
n3:domaciTvurceVysledku
n4:7777434 n4:5599830 n4:1449052 n4:3102521 n4:8692025 n4:1212001
n3:druhVysledku
n9:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
219336
n3:idVysledku
RIV/62157124:16370/11:43870392
n3:jazykVysledku
n18:eng
n3:klicovaSlova
oxidized cellulose; microencapsulation; lag time; external gelation; controlled release
n3:klicoveSlovo
n7:microencapsulation n7:lag%20time n7:controlled%20release n7:oxidized%20cellulose n7:external%20gelation
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[EED35DC4CEBD]
n3:nazevZdroje
AAPS PHARMSCITECH
n3:obor
n12:FR
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
7
n3:projekt
n20:2A-1TP1%2F073
n3:rokUplatneniVysledku
n15:2011
n3:svazekPeriodika
12
n3:tvurceVysledku
Dvořáčková, Kateřina Krejčová, Kateřina Bajerová, Martina Rabišková, Miloslava Masteiková, Ruta Gajdziok, Jan Muselík, Jan
n3:wos
000297586500036
s:issn
1530-9932
s:numberOfPages
10
n16:doi
10.1208/s12249-011-9696-9
n19:organizacniJednotka
16370