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Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F10%3A00002639%21RIV11-MSM-16370___
rdf:type
skos:Concept n13:Vysledek
dcterms:description
Flavonoids are commonly studied for their anti-inflammatory effects; however, this is the first paper describing the possible antiphlogistic activity of a geranylated flavanone. This study focused on the ability of diplacone to modulate the gene expression of pro-inflammatory tumour necrosis factor a and monocyte chemoattractant protein 1, and of anti-inflammatory zinc finger protein 36. The action of diplacone was also compared with that of conventional drug indomethacin. Human monocyte-derived macrophages of the human monocytic leukaemia cell line were pretreated with diplacone or indomethacin. Subsequently, inflammatory reaction was induced by lipopolysaccharide, and changes of tumour necrosis factor a, monocyte chemoattractant protein 1 and zinc finger protein 36 gene expression at the transcriptional level were measured. In this model, diplacone significantly down-regulated the expression of tumour necrosis factor a and monocyte chemoattractant protein 1 and up-regulated the zinc finger protein 3 Flavonoids are commonly studied for their anti-inflammatory effects; however, this is the first paper describing the possible antiphlogistic activity of a geranylated flavanone. This study focused on the ability of diplacone to modulate the gene expression of pro-inflammatory tumour necrosis factor a and monocyte chemoattractant protein 1, and of anti-inflammatory zinc finger protein 36. The action of diplacone was also compared with that of conventional drug indomethacin. Human monocyte-derived macrophages of the human monocytic leukaemia cell line were pretreated with diplacone or indomethacin. Subsequently, inflammatory reaction was induced by lipopolysaccharide, and changes of tumour necrosis factor a, monocyte chemoattractant protein 1 and zinc finger protein 36 gene expression at the transcriptional level were measured. In this model, diplacone significantly down-regulated the expression of tumour necrosis factor a and monocyte chemoattractant protein 1 and up-regulated the zinc finger protein 3
dcterms:title
Effect of Diplacone on LPS-Induced Inflammatory Gene Expression in Macrophages Effect of Diplacone on LPS-Induced Inflammatory Gene Expression in Macrophages
skos:prefLabel
Effect of Diplacone on LPS-Induced Inflammatory Gene Expression in Macrophages Effect of Diplacone on LPS-Induced Inflammatory Gene Expression in Macrophages
skos:notation
RIV/62157124:16370/10:00002639!RIV11-MSM-16370___
n3:aktivita
n11:V n11:S
n3:aktivity
S, V
n3:cisloPeriodika
3
n3:dodaniDat
n10:2011
n3:domaciTvurceVysledku
n9:4281888 n9:4091647 n9:4373510 n9:3893596
n3:druhVysledku
n4:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
255953
n3:idVysledku
RIV/62157124:16370/10:00002639
n3:jazykVysledku
n14:eng
n3:klicovaSlova
geranyl flavanone; inflammation; MCP-1; mRNA; TNF-alpha; ZFP36
n3:klicoveSlovo
n7:mRNA n7:MCP-1 n7:ZFP36 n7:inflammation n7:TNF-alpha n7:geranyl%20flavanone
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[3C3DDD735B6A]
n3:nazevZdroje
Folia Biologica (Praha)
n3:obor
n16:FR
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n10:2010
n3:svazekPeriodika
56
n3:tvurceVysledku
Hošek, Jan Šmejkal, Karel Závalová, Veronika Bartoš, Milan
n3:wos
000279493800005
s:issn
0015-5500
s:numberOfPages
7
n15:organizacniJednotka
16370