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Statements

Subject Item
n2:RIV%2F62157124%3A16370%2F09%3A00002079%21RIV10-MSM-16370___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
The study examined the antimicrobial activity of 2-hydroxy-3-[4-(2-fluoro, 4-fluoro, and 2-metoxyphenyl)-piperazin-l-yl]-propyl- 4-[(alkoxycarbonyl)amino] benzoates, their salts with hydrochloric acid, with one to four carbon atoms in the alkoxy group of the carbamoyl group studied and described. The series of these substances were evaluated in vitro against Mycobacterium kansasii 6 509/96. The correlation of this activity with lipophilicity (log k') was used to describe the structure-antimycobacterial activity relationships (QSARs). The tests have shown that practically all the substances under study possess antituberculotic activity. In vitro antimycobacterial activity increased with increasing lipophilicity. According to the obtained results, the substances can be considered as potential antituberculotics. The study examined the antimicrobial activity of 2-hydroxy-3-[4-(2-fluoro, 4-fluoro, and 2-metoxyphenyl)-piperazin-l-yl]-propyl- 4-[(alkoxycarbonyl)amino] benzoates, their salts with hydrochloric acid, with one to four carbon atoms in the alkoxy group of the carbamoyl group studied and described. The series of these substances were evaluated in vitro against Mycobacterium kansasii 6 509/96. The correlation of this activity with lipophilicity (log k') was used to describe the structure-antimycobacterial activity relationships (QSARs). The tests have shown that practically all the substances under study possess antituberculotic activity. In vitro antimycobacterial activity increased with increasing lipophilicity. According to the obtained results, the substances can be considered as potential antituberculotics.
dcterms:title
Antimycobacterial activity of novel derivatives of arylcarbonyloxyaminopropanols Antimycobacterial activity of novel derivatives of arylcarbonyloxyaminopropanols
skos:prefLabel
Antimycobacterial activity of novel derivatives of arylcarbonyloxyaminopropanols Antimycobacterial activity of novel derivatives of arylcarbonyloxyaminopropanols
skos:notation
RIV/62157124:16370/09:00002079!RIV10-MSM-16370___
n3:aktivita
n16:S
n3:aktivity
S
n3:cisloPeriodika
5-6
n3:dodaniDat
n8:2010
n3:domaciTvurceVysledku
n6:8728968 n6:7985479
n3:druhVysledku
n13:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
303496
n3:idVysledku
RIV/62157124:16370/09:00002079
n3:jazykVysledku
n4:eng
n3:klicovaSlova
Antimycobacterial activity; Antituberculotic activity; Arylcarbonyloxyaminopropanols; Lipophilicity; Phenylcarbamates; Potential antituberculotics
n3:klicoveSlovo
n9:Phenylcarbamates n9:Antimycobacterial%20activity n9:Antituberculotic%20activity n9:Potential%20antituberculotics n9:Lipophilicity n9:Arylcarbonyloxyaminopropanols
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[D1916A031D47]
n3:nazevZdroje
Česká a slovenská farmacie
n3:obor
n11:FR
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n8:2009
n3:svazekPeriodika
58
n3:tvurceVysledku
Csöllei, Jozef Malík, Ivan Andriamainty, Fils Čižmárik, Jozef Mokrý, Petr Kečkéšová, Simona Kaustová, Jarmila Garaj, Vladimír Sedlárová, Eva
s:issn
1210-7816
s:numberOfPages
5
n17:organizacniJednotka
16370